| pubmed-article:699481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C0008168 | lld:lifeskim |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C0031412 | lld:lifeskim |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C0031507 | lld:lifeskim |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C0085973 | lld:lifeskim |
| pubmed-article:699481 | lifeskim:mentions | umls-concept:C0007320 | lld:lifeskim |
| pubmed-article:699481 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:699481 | pubmed:dateCreated | 1978-12-29 | lld:pubmed |
| pubmed-article:699481 | pubmed:abstractText | The effect of chloramphenicol therapy (48 mg/kg/day) on the serum concentrations of phenytoin and phenobarbital was studied in a patient previously stabilized on anticonvulsant medications. Phenytoin, 12 mg/kg/day, and phenobarbital, 5 mg/kg/day resulted in serum concentrations averaging 10.8 microgram/ml before and 30.5 microgram/ml, after chloramphenicol therapy. A reduction in dose of both phenytoin and phenobarbital was required to minimize adverse effects during the course of chloramphenicol therapy. An average daily dose of phenytoin of 9.1 mg/kg resulted in an average serum concentration of 17.8 microgram/ml. A daily dose of phenobarbital of 4.0 mg/kg resulted in an average serum concentration of 37.1 microgram/ml. These changes indicate 50.5% and 40.4% decreases in clearance of phenytoin and phenobarbital. Multiple-dose nonlinear regression analysis of phenytoin and phenobarbital serum concentration data obtained during chloramphenicol therapy indicated a 62.5% and a 29.5% decrease in clearance. Subsequent serum concentration monitoring demonstrated a similar reduction in phenobarbital clearance when chloramphenicol was added to phenobarbital alone. | lld:pubmed |
| pubmed-article:699481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:699481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:699481 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:699481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:699481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:699481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:699481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:699481 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:699481 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:GibaldiMM | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:KoupJ RJR | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:ColburnW AWA | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:BruceOO | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:McNamaraPP | lld:pubmed |
| pubmed-article:699481 | pubmed:author | pubmed-author:HilligossD... | lld:pubmed |
| pubmed-article:699481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:699481 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:699481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:699481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:699481 | pubmed:pagination | 571-5 | lld:pubmed |
| pubmed-article:699481 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-H... | lld:pubmed |
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| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-C... | lld:pubmed |
| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-K... | lld:pubmed |
| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-A... | lld:pubmed |
| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-P... | lld:pubmed |
| pubmed-article:699481 | pubmed:meshHeading | pubmed-meshheading:699481-D... | lld:pubmed |
| pubmed-article:699481 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:699481 | pubmed:articleTitle | Interaction of chloramphenicol with phenytoin and phenobarbital. Case report. | lld:pubmed |
| pubmed-article:699481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:699481 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:699481 | pubmed:publicationType | Case Reports | lld:pubmed |
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