| pubmed-article:6980935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:6980935 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:6980935 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6980935 | pubmed:dateCreated | 1982-10-29 | lld:pubmed |
| pubmed-article:6980935 | pubmed:abstractText | In this report we examined the effects of trypsin treatment of immune guinea pig T lymphocytes on their binding to syngeneic macrophages. Immune T cells positively selected by culture for 1 wk with antigen and treated with trypsin showed dramatic binding to macrophages in the absence of additional antigen. This binding was rapid and greatest at 1 hr after the addition of trypsin-treated T cells to macrophages. Thereafter, the bound T cells dissociated from the macrophages and did not rebind. Dissociation of macrophage-bound T cells appeared to be an active process that could be inhibited by blocking T cell protein synthesis. Macrophage binding by trypsin-treated T cells was dependent on prior in vitro stimulation; similar treatment of immune T cells taken directly from the animal did not augment binding, and treatment of T cells cultured without antigen resulted in only modest binding. In addition, the trypsin-induced binding phenomenon showed elements of genetic restrictions. Trypsin treatment of immune T cells selected by culture for 1 wk with antigen resulted in preferential binding to syngeneic macrophages. In addition, immune F1 T cells selected by culture with antigen-pulsed parental macrophages preferentially bound to macrophages of the haplotype used for selection. Evidence is presented suggesting that the trypsin-induced binding was not simply due to antigen carry-over from the trypsinized lymphocytes and favoring the possibility that this binding may be antigen-independent. These results suggest that antigen-activated T cells express covert interaction sites for macrophages and that these sites are actively covered-up by other membrane components. | lld:pubmed |
| pubmed-article:6980935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980935 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980935 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6980935 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980935 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6980935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6980935 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6980935 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6980935 | pubmed:author | pubmed-author:ThomasD WDW | lld:pubmed |
| pubmed-article:6980935 | pubmed:author | pubmed-author:HoffmanM DMD | lld:pubmed |
| pubmed-article:6980935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6980935 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:6980935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6980935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6980935 | pubmed:pagination | 1416-20 | lld:pubmed |
| pubmed-article:6980935 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:meshHeading | pubmed-meshheading:6980935-... | lld:pubmed |
| pubmed-article:6980935 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6980935 | pubmed:articleTitle | Evidence for covert cellular interaction sites expressed by activated T lymphocytes. | lld:pubmed |
| pubmed-article:6980935 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6980935 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
