| pubmed-article:6979567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C0026385 | lld:lifeskim |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:6979567 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6979567 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6979567 | pubmed:dateCreated | 1982-8-7 | lld:pubmed |
| pubmed-article:6979567 | pubmed:abstractText | The production of multipotential hemopoietic stem cells (CFUs) in cultures of murine bone marrow cells is supported by medium conditioned by concanavalin A-stimulated T cell hybridoma 123 or spleen cells. We present physiochemical evidence that this activity of these conditioned media, which we have operationally termed CFUs-stimulating activity (CFUs-SA), is due to a new T cell-derived lymphokine. CFUs-SA was shown by gel filtration to reside in a distinct fraction corresponding to a mean apparent m.w. of 29,000, and was distinguishable from T cell growth factor, not only by its lower apparent m.w. but also by chromatography using Phenyl-Sepharose. After isoelectric focusing of neuraminidase-treated conditioned medium, CFUs-SA was found between isoelectric points 5 and 8. In this respect, CFUs-SA appeared similar to another factor, P cell-stimulating factor, which stimulates the growth of persisting (P) cells (homogeneous populations of cells resembling mast cells) and that occurred together with CFUs-SA in both the spleen and hybridoma-conditioned media. Isoelectric focusing separated CFUs-SA from granulocyte-macrophage colony-stimulating factor, which focused as a single peak with an isoelectric point around 5.0. Thus CFUs-SA is due to a T cell-derived factor that is separable from T cell growth factor and T cell-derived granulocyte-macrophage colony-stimulating factor, but has similar properties to P cell-stimulating factor. | lld:pubmed |
| pubmed-article:6979567 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6979567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6979567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6979567 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6979567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6979567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6979567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6979567 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6979567 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6979567 | pubmed:author | pubmed-author:SchraderJ WJW | lld:pubmed |
| pubmed-article:6979567 | pubmed:author | pubmed-author:Clark-LewisII | lld:pubmed |
| pubmed-article:6979567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6979567 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:6979567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6979567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6979567 | pubmed:pagination | 30-5 | lld:pubmed |
| pubmed-article:6979567 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6979567 | pubmed:meshHeading | pubmed-meshheading:6979567-... | lld:pubmed |
| pubmed-article:6979567 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6979567 | pubmed:articleTitle | A T cell-derived factor stimulating multipotential hemopoietic stem cells: molecular weight and distinction from T cell growth factor and T cell-derived granulocyte-macrophage colony-stimulating factor. | lld:pubmed |
| pubmed-article:6979567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6979567 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6979567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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