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pubmed-article:6975514pubmed:abstractTextPositron emission tomography (PET) makes it possible to employ an in vivo autoradiographic paradigm to measure regional cerebral blood flow (rCBF) in man. In this study, we synthesized the positron-emitting radiopharmaceutical 11C-iodoantipyrine (11C-IAP) and validated its suitability as a CBF tracer. 11C ( T and one-half 20.4 min) was produced by the (p,alpha) nuclear reaction on 14N. 11C-methyl iodide was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form 11C-antipyrine, which was iodinated. Radiochemical purity of the 11C-IAP product was 93-98% except as described below. rCBF was measured with 11C-IAP in nitrous oxide-anesthetized Wistar rats by the method of indicator fractionation, and values were compared with rCBF values measured with simultaneously administered commercially produced 14C-IAP. rCBF was studied over a range of arterial Pco2 values (31-58 mm Hg, mean 43.0 +/- 3.5). Mean rCBF data for the 2 tracers agreed to within 4.8% for cerebral hemispheral samples, 3.8% for cerebellum, and 5.3% for brainstem. Mean values (+/- SEM) for rCBF using 11C-IAP were 1.67 +/- 0.20 ml gm-1 min-1 for cerebral hemispheres; 1.32 +/- 0.17 for cerebellum; and 1.50 +/- 0.21 for brainstem. When chromatographic analysis revealed tracer impurity, rCBF, as measured with 11C-IAP, fell consistently below values obtained with 14C-IAP. The data indicate that 11C-IAP, when properly synthesized and submitted to batch-by-batch quality control, may be suitable for measuring rCBF in man by emission tomography.lld:pubmed
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pubmed-article:6975514pubmed:authorpubmed-author:CampbellJ AJAlld:pubmed
pubmed-article:6975514pubmed:authorpubmed-author:GinsbergM DMDlld:pubmed
pubmed-article:6975514pubmed:authorpubmed-author:LockwoodA HAHlld:pubmed
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pubmed-article:6975514pubmed:authorpubmed-author:FinnR DRDlld:pubmed
pubmed-article:6975514pubmed:authorpubmed-author:BootheT ETElld:pubmed
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pubmed-article:6975514pubmed:volume12lld:pubmed
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pubmed-article:6975514pubmed:pagination745-50lld:pubmed
pubmed-article:6975514pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:6975514pubmed:articleTitle11C-Iodoantipyrine for the measurement of regional cerebral blood flow by positron emission tomography. Validation studies.lld:pubmed
pubmed-article:6975514pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6975514pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed