| pubmed-article:6965296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6965296 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:6965296 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6965296 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:6965296 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:6965296 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6965296 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6965296 | pubmed:dateCreated | 1980-2-28 | lld:pubmed |
| pubmed-article:6965296 | pubmed:abstractText | Spleen cells of BALB/c mice immunized with purified BALB/c myeloma protein (MP) caused idiotype-specific suppression of DNA synthesis and colony formation by myeloma cells in vitro. Lymphocytes from mice immunized with 315-MP inhibited only MOPC-315 plasmacytoma cells; conversely, lymphocytes from mice immunized with 167-MP inhibited only MOPC-167 plasmacytoma cells. Antisera from those mice that showed cell-mediated inhibition of myeloma growth had no significant effect. The suppressive activity of the spleen cells was markedly reduced by treatment with anti-Thy 1.2 and complement, and the immune cells responsible for the suppression did not adhere to nylon wool. The suppressor cells adsorbed to myeloma protein-coated plates, and after elution, inhibited myeloma cells specifically at a 1:1 effector to target cell ratio. Suppression of myeloma growth was due to cytostatic rather than cytolytic effects. These findings suggest that mice immunized with purified myeloma protein have idiotype-specific T cells that can regulate myeloma cell growth. This mechanism may provide an explanation for the transplantation resistance to myelomas induced by immunization with myeloma protein. Similar idiotype-specific T cells may also play a role in the idiotype-specific regulation of immune responses by acting late in differentiation to block the proliferation of antibody-secreting normal B cells. | lld:pubmed |
| pubmed-article:6965296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6965296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6965296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6965296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6965296 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6965296 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6965296 | pubmed:author | pubmed-author:PhilippuAA | lld:pubmed |
| pubmed-article:6965296 | pubmed:author | pubmed-author:SchreiberHH | lld:pubmed |
| pubmed-article:6965296 | pubmed:author | pubmed-author:FloodP MPM | lld:pubmed |
| pubmed-article:6965296 | pubmed:author | pubmed-author:TaupierM AMA | lld:pubmed |
| pubmed-article:6965296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6965296 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:6965296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6965296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6965296 | pubmed:pagination | 424-30 | lld:pubmed |
| pubmed-article:6965296 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6965296 | pubmed:meshHeading | pubmed-meshheading:6965296-... | lld:pubmed |
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| pubmed-article:6965296 | pubmed:meshHeading | pubmed-meshheading:6965296-... | lld:pubmed |
| pubmed-article:6965296 | pubmed:meshHeading | pubmed-meshheading:6965296-... | lld:pubmed |
| pubmed-article:6965296 | pubmed:meshHeading | pubmed-meshheading:6965296-... | lld:pubmed |
| pubmed-article:6965296 | pubmed:meshHeading | pubmed-meshheading:6965296-... | lld:pubmed |
| pubmed-article:6965296 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6965296 | pubmed:articleTitle | Regulation of myeloma growth in vitro by idiotype-specific T lymphocytes. | lld:pubmed |
| pubmed-article:6965296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6965296 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6965296 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6965296 | lld:pubmed |
