| pubmed-article:6958215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6958215 | lifeskim:mentions | umls-concept:C0085494 | lld:lifeskim |
| pubmed-article:6958215 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6958215 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6958215 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:6958215 | lifeskim:mentions | umls-concept:C0076433 | lld:lifeskim |
| pubmed-article:6958215 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6958215 | pubmed:dateCreated | 1982-12-16 | lld:pubmed |
| pubmed-article:6958215 | pubmed:abstractText | The minimal bactericidal concentrations of N-formimidoyl thienamycin (N-f-thienamycin) against 21 strains of enterococci isolated from patients with infective endocarditis were determined by macro- and microdilution methods. By a macrodilution technique with the minimal bactericidal concentration defined as greater than or equal to 99.9% killing of an initial inoculum, all 21 strains of enterococci were found to have minimal bactericidal concentration/minimal inhibitory concentration ratios of greater than or equal to 32. The mean minimal inhibitory concentration was 1.5 micrograms/ml (range, 0.5 to 4 micrograms/ml), and the minimal bactericidal concentration was greater than or equal to 128 micrograms/ml. The disparity between the results of our study and those published elsewhere, which reported that N-f-thienamycin is bactericidal in vitro against enterococci, may represent the relative insensitivity of the microdilution method in determining greater than or equal to 99.9% killing. The lack of in vitro bactericidal activity of N-f-thienamycin against enterococci was confirmed in vivo in the rabbit model of experimental endocarditis. N-f-Thienamycin was no more effective than penicillin alone in the treatment of experimental enterococcal endocarditis and was less effective than the combination of penicillin and gentamicin. The results indicate that N-f-thienamycin should not be used alone in the treatment of enterococcal endocarditis. | lld:pubmed |
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| pubmed-article:6958215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6958215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6958215 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6958215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6958215 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6958215 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:WashingtonJ... | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:DurackD TDT | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:GeraciJ EJE | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:WilsonW RWR | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:AuckenthalerR... | lld:pubmed |
| pubmed-article:6958215 | pubmed:author | pubmed-author:WrightA JAJ | lld:pubmed |
| pubmed-article:6958215 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6958215 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:6958215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6958215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6958215 | pubmed:pagination | 448-52 | lld:pubmed |
| pubmed-article:6958215 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6958215 | pubmed:meshHeading | pubmed-meshheading:6958215-... | lld:pubmed |
| pubmed-article:6958215 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6958215 | pubmed:articleTitle | Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci. | lld:pubmed |
| pubmed-article:6958215 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6958215 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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