| pubmed-article:6956630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:6956630 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6956630 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6956630 | pubmed:dateCreated | 1982-12-3 | lld:pubmed |
| pubmed-article:6956630 | pubmed:abstractText | Resident peritoneal M phi of C3H/HeN mice co-cultured with splenic lymphocytes suppressed proliferation to mitogens. This M phi-mediated suppression was significantly reduced by in vitro treatment of M phi with fibroblast interferon (IFN-beta). Conversely, M phi-mediated natural tumor cytolysis was augmented by M phi treatment with IFN-beta. Depletion of Ia-bearing (Ia+) M phi by means of anti-Ia serum and C treatment did not affect M phi-mediated suppression or M phi-mediated natural cytotoxicity. This suggested that Ia-negative (Ia-) M phi were responsible for the effector phase of these two M phi functions. The IFN-beta-induced increase in M phi cytolysis was not affected by depletion of Ia+ cells; however, modulation of suppressive activity by IFN-beta was found to be highly dependent on the presence of Ia+ M phi. This observation indicated that different M phi subpopulations were involved in the regulation of suppressive and tumoricidal activity. The results indicating different regulatory M phi were supported by experiments with C3H/HeJ mice. C3H/HeJ M phi do not develop high cytolytic activity in response to a variety of stimuli; however, M phi from C3H/HeJ mice were able to exert suppressive activity, which was reduced by treatment with IFN-beta. | lld:pubmed |
| pubmed-article:6956630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6956630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6956630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6956630 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6956630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6956630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6956630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6956630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6956630 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6956630 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6956630 | pubmed:author | pubmed-author:BoraschiDD | lld:pubmed |
| pubmed-article:6956630 | pubmed:author | pubmed-author:NiederhuberJ... | lld:pubmed |
| pubmed-article:6956630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6956630 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:6956630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6956630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6956630 | pubmed:pagination | 1854-8 | lld:pubmed |
| pubmed-article:6956630 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6956630 | pubmed:meshHeading | pubmed-meshheading:6956630-... | lld:pubmed |
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| pubmed-article:6956630 | pubmed:meshHeading | pubmed-meshheading:6956630-... | lld:pubmed |
| pubmed-article:6956630 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6956630 | pubmed:articleTitle | Regulation of macrophage suppression and cytotoxicity by interferon role of Ia-bearing macrophages. | lld:pubmed |
| pubmed-article:6956630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6956630 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6956630 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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