| pubmed-article:6928679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6928679 | lifeskim:mentions | umls-concept:C0034085 | lld:lifeskim |
| pubmed-article:6928679 | lifeskim:mentions | umls-concept:C0001109 | lld:lifeskim |
| pubmed-article:6928679 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:6928679 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6928679 | pubmed:dateCreated | 1980-5-14 | lld:pubmed |
| pubmed-article:6928679 | pubmed:abstractText | Lung surfactant, a lipid-protein complex purified from dog lungs, contains a highly active phosphomonoesterase associated with it. This phosphatase is quite specific for the hydrolysis of phosphatidic acid and 1-acyl-2-lysophosphatidic acid. The enzyme possesses many of the characteristics of the microsomal enzyme, phosphatidate phosphohydrolase (EC 3.1.3.4). In addition, we have shown that this enzyme will also convert phosphatidylglycerol phosphate [1-(3-sn-phosphatidyl)-sn-glycerol-1-P] to phosphatidylglycerol [1-(3-sn-phosphatidyl)-sn-glycerol] and Pi. The phosphatidylglycerol phosphate was made available to the surfactant enzyme in a coupled assay by hydrolysis of cardiolipin [1-(3-sn-phosphatidyl)-3-(3-sn-phosphatidyl)-sn-glycerol] by stereospecific cleavage with phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC 3.1.4.3) from Bacillus cereus. This enzyme has been previously shown to generate the naturally occurring isomer of phosphatidylglycerol phosphate because it has specificity for the 3-(3-sn-phosphatidyl) group of cardiolipin. Other properties of the surfactant enzyme are discussed in relation to its presence in lung surface active material. | lld:pubmed |
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| pubmed-article:6928679 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6928679 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6928679 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6928679 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6928679 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6928679 | pubmed:author | pubmed-author:BensonB JBJ | lld:pubmed |
| pubmed-article:6928679 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6928679 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:6928679 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6928679 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6928679 | pubmed:pagination | 808-11 | lld:pubmed |
| pubmed-article:6928679 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6928679 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6928679 | pubmed:articleTitle | Properties of an acid phosphatase in pulmonary surfactant. | lld:pubmed |
| pubmed-article:6928679 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6928679 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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