| pubmed-article:6895340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0521378 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0037494 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0008402 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0072186 | lld:lifeskim |
| pubmed-article:6895340 | lifeskim:mentions | umls-concept:C0102397 | lld:lifeskim |
| pubmed-article:6895340 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6895340 | pubmed:dateCreated | 1982-1-20 | lld:pubmed |
| pubmed-article:6895340 | pubmed:abstractText | 1 Hypolipidaemic agents may increase biliary cholesterol in man, inducing a supersaturated bile. 2 To evaluate this possible side-effect, we have studied bile lipid secretion over a period of 8 h with intact enterohepatic circulation and 4 h with complete interruption in rats treated for two months with a salt of cholestyramine and 2-[4-(p-chlorobenzoyl)-phenoxy]2-methyl propionic acid (alpha-1081, 1.150 g/kg body wt., daily), cholestyramine (1.125 g/kg body wt. daily), procetofenic acid (25 mg/kg body wt. daily) and saline respectively (six rats for each group). 3 Cholesterol saturation index significantly (P less than 0.005) increased (from 0.21 +/- 0.01 to 0.39 +/- 0.09, mean +/- s.d.), in rats fed with procetofenic acid but it did not in alpha-1081- and cholestyramine-treated animals. 4 Procetofenic acid and, to a lesser extent, cholestyramine increased the bile flow. Procetofenic acid increased cholesterol secretion from 0.45 +/- 0.17 to 0.94 +/- 0.19 mumol kg-1 body wt. h-1 (mean +/- s.d.). 5 Cholestyramine increased both serum cholesterol and bile acid secretion from 0.45 +/- 0.17 to 0.68 +/- 0.10 and 25.8 +/- 9.48 to 39.96 +/- 6.68 mumol kg-1 body wt. h-1 respectively; alpha-1081, on the contrary, had no effect on bile lipid secretion. 6 These data suggest that alpha-1081 may be used as a new hypolipidaemic drug without any risk of increasing cholesterol in bile. | lld:pubmed |
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| pubmed-article:6895340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6895340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6895340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6895340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6895340 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6895340 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:BarbaraLL | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:RodaEE | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:AldiniRR | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:GeminianiSS | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:MascellaniGG | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:RodaAA | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:BenelliAA | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:MorselliAA | lld:pubmed |
| pubmed-article:6895340 | pubmed:author | pubmed-author:BorzattaVV | lld:pubmed |
| pubmed-article:6895340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6895340 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:6895340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6895340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6895340 | pubmed:pagination | 611-7 | lld:pubmed |
| pubmed-article:6895340 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:6895340 | pubmed:meshHeading | pubmed-meshheading:6895340-... | lld:pubmed |
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| pubmed-article:6895340 | pubmed:meshHeading | pubmed-meshheading:6895340-... | lld:pubmed |
| pubmed-article:6895340 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6895340 | pubmed:articleTitle | Effects of a salt of cholestyramine and 2-[4-(p-chlorobenzoyl)phenoxy]2-methyl propionic acid (alpha-1081) on biliary lipid secretion in rats. | lld:pubmed |
| pubmed-article:6895340 | pubmed:publicationType | Journal Article | lld:pubmed |
