pubmed-article:6849951 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0103839 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0205666 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C0015252 | lld:lifeskim |
pubmed-article:6849951 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
pubmed-article:6849951 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:6849951 | pubmed:dateCreated | 1983-7-8 | lld:pubmed |
pubmed-article:6849951 | pubmed:abstractText | Apolipoprotein B, the major structural protein of triacylglycerol-rich lipoprotein, occurs in two immunologically distinct forms, termed apolipoproteins B-100 and B-48. In man, the former is associated with triacylglycerol-rich lipoproteins of hepatic origin and the latter with intestinal triacylglycerol-rich lipoproteins. We have studied the rates of removal of the two proteins when 125I-labelled triacylglycerol-rich lipoproteins were reinjected into six severely hypertriglyceridemic subjects showing hyperchylomicronemia, and into two normal subjects. The specific radioactivities of apolipoproteins B-100 and B-48 were determined over periods of up to 30 h. In all six hyperlipemic subjects the removal of apolipoprotein B-100 was either significantly faster than that of apolipoprotein B-48 (in four) or similar in the two who cleared triacylglycerol-rich lipoproteins very slowly. When triacylglycerol-rich lipoproteins from two hyperlipemic subjects (in whom apolipoprotein B-48 was cleared more slowly) were injected into two normal subjects both B apolipoproteins were cleared at similar rates. Since apolipoprotein B-48 appears to be a marker for remnants of intestinal particles, its slower removal than that of apolipoprotein B-100 in severe hypertriglyceridemia suggests that one metabolic defect associated with the hyperchylomicronemia is defective removal of chylomicron remnants. | lld:pubmed |
pubmed-article:6849951 | pubmed:language | eng | lld:pubmed |
pubmed-article:6849951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6849951 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:6849951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6849951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6849951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6849951 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6849951 | pubmed:month | May | lld:pubmed |
pubmed-article:6849951 | pubmed:issn | 0006-3002 | lld:pubmed |
pubmed-article:6849951 | pubmed:author | pubmed-author:BillingtonTT | lld:pubmed |
pubmed-article:6849951 | pubmed:author | pubmed-author:NestelP JPJ | lld:pubmed |
pubmed-article:6849951 | pubmed:author | pubmed-author:FidgeN HNH | lld:pubmed |
pubmed-article:6849951 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6849951 | pubmed:day | 16 | lld:pubmed |
pubmed-article:6849951 | pubmed:volume | 751 | lld:pubmed |
pubmed-article:6849951 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6849951 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6849951 | pubmed:pagination | 422-7 | lld:pubmed |
pubmed-article:6849951 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:6849951 | pubmed:year | 1983 | lld:pubmed |
pubmed-article:6849951 | pubmed:articleTitle | Slower removal of intestinal apolipoprotein B-48 than of apolipoprotein B-100 in severely hypertriglyceridemic subjects. | lld:pubmed |
pubmed-article:6849951 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6849951 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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