| pubmed-article:6832215 | pubmed:abstractText | Sinoaortic denervated rats, 24 h after operation, showed a 25% increase in the central (hypothalamus, frontal cortex, midbrain, pons and medulla oblongata) tryptophan content and about a 70% rise in plasma free fatty acid (NEFA) concentration. The synaptosomal serotonin (5-HT) uptake and tryptophan hydroxylase activity of slices from these central areas were not significantly different when compared to those from sham-operated rats. There was also an increase in tryptophan and NEFA concentration at 24 h in fasted sham-operated rats. Seven days after neurogenic hypertension, the central tryptophan content had returned to control values. However, a 50% increase in the tryptophan hydroxylase activity of slices from the midbrain area together with a higher turnover rate of serotonin was found in the denervated group of rats. The synaptosomal 5-HT uptake remained unchanged. These results suggest that sinoaortic denervation could induce changes in the serotonergic neurons localized in central nervous system areas during the first week after operation. | lld:pubmed |
