| pubmed-article:6823884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C0008370 | lld:lifeskim |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C0039350 | lld:lifeskim |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C0075575 | lld:lifeskim |
| pubmed-article:6823884 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:6823884 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6823884 | pubmed:dateCreated | 1983-3-11 | lld:pubmed |
| pubmed-article:6823884 | pubmed:abstractText | The hypothesis that the amino acid used for the conjugation of sulfolithocholate (S-LCA) is a critical determinant of its cholestatic potential was tested in the guinea pig which conjugates 90% of its bile acids with glycine. Twelve groups of animals were used to study the effect of taurine feeding at a concentration of 0.5% in the drinking water for periods of 1, 3, and 5 days before an iv injection of 18 mumol/100 g body weight of S-LCA. Bile flow was monitored in 30-min aliquots over a 3-h period and the bile acid secretion as well as the glycine/taurine ratio of conjugated bile acids were determined. At the end of the various time periods, the livers were examined by light and electron microscopy. Within 3 days after taurine administration there was an increase in bile flow and a reversal of the glycine/taurine ratio with taurine conjugates becoming predominant. Liver morphology was unchanged except for a slight accumulation of lipids after 5 days of taurine feeding. In animals who were not pretreated with taurine, S-LCA injection led to a progressive decrease in bile flow such, that it was reduced to less than 20% at the end of the 3-h collection. S-LCA was conjugated almost exclusively with glycine. In contrast, in the groups fed taurine for 1, 3, and 5 days before the S-LCA injection, bile flow was comparable to that of the groups fed taurine alone. The S-LCA recovered in bile was to a large extent conjugated with taurine. S-LCA animals pretreated with taurine did not exhibit any liver cell changes while the group which had not received taurine before the S-LCA injection showed numerous cytoplasmic vacuoles with normal bile canaliculi. These data show that increasing the availability of taurine through dietary means may exert a protective effect against cholestasis induced by monohydroxy bile acids. | lld:pubmed |
| pubmed-article:6823884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6823884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6823884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6823884 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6823884 | pubmed:issn | 0002-9165 | lld:pubmed |
| pubmed-article:6823884 | pubmed:author | pubmed-author:RoyC CCC | lld:pubmed |
| pubmed-article:6823884 | pubmed:author | pubmed-author:YousefI MIM | lld:pubmed |
| pubmed-article:6823884 | pubmed:author | pubmed-author:TuchweberBB | lld:pubmed |
| pubmed-article:6823884 | pubmed:author | pubmed-author:DorvilN PNP | lld:pubmed |
| pubmed-article:6823884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6823884 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:6823884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6823884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6823884 | pubmed:pagination | 221-32 | lld:pubmed |
| pubmed-article:6823884 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
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| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
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| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:meshHeading | pubmed-meshheading:6823884-... | lld:pubmed |
| pubmed-article:6823884 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6823884 | pubmed:articleTitle | Taurine prevents cholestasis induced by lithocholic acid sulfate in guinea pigs. | lld:pubmed |
| pubmed-article:6823884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6823884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6823884 | lld:pubmed |
