| pubmed-article:6823519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C0162429 | lld:lifeskim |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:6823519 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:6823519 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6823519 | pubmed:dateCreated | 1983-3-24 | lld:pubmed |
| pubmed-article:6823519 | pubmed:abstractText | When rats are exposed to a sufficiently large dose of ionizing radiation they exhibit lethargy, hypokinesia, and deficits in performance. These and other behavioral changes parallel those often observed in this species after a large dose of morphine. Since the release of endogenous opiates has been implicated in some stress reactions, we sought to determine if they might play a part in radiogenic behavioral deficits. Rats were trained to criterion on a signaled avoidance task. Some subjects were then implanted with a pellet containing 75 mg of morphine. Other animals received placebo implants. Over a number of days, morphine tolerance was evaluated by measurement of body temperature changes. Prior to 2500 rad 60Co exposure or sham irradiation, morphine (or placebo) pellets were removed. Twenty-four hours later rats were retested to assess their performance on the avoidance task. Morphine-tolerant subjects performed significantly better than the irradiated placebo-implanted group and no differently than morphine-tolerant/sham-irradiated animals. Morphine tolerance seems to provide a degree of behavioral radiation resistance. These data are consistent with the hypothesis that endogenous opiate hyperexcretion may play some part in the behavioral deficits often observed after irradiation. | lld:pubmed |
| pubmed-article:6823519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6823519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6823519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6823519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6823519 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6823519 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:6823519 | pubmed:author | pubmed-author:WhiteG AGA | lld:pubmed |
| pubmed-article:6823519 | pubmed:author | pubmed-author:MickleyG AGA | lld:pubmed |
| pubmed-article:6823519 | pubmed:author | pubmed-author:StevensK EKE | lld:pubmed |
| pubmed-article:6823519 | pubmed:author | pubmed-author:GibbsG LGL | lld:pubmed |
| pubmed-article:6823519 | pubmed:author | pubmed-author:BurrowsJ MJM | lld:pubmed |
| pubmed-article:6823519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6823519 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:6823519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6823519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6823519 | pubmed:pagination | 381-7 | lld:pubmed |
| pubmed-article:6823519 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:meshHeading | pubmed-meshheading:6823519-... | lld:pubmed |
| pubmed-article:6823519 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6823519 | pubmed:articleTitle | Morphine tolerance offers protection from radiogenic performance deficits. | lld:pubmed |
| pubmed-article:6823519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6823519 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
