| pubmed-article:6815691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6815691 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:6815691 | lifeskim:mentions | umls-concept:C0459385 | lld:lifeskim |
| pubmed-article:6815691 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:6815691 | lifeskim:mentions | umls-concept:C0002600 | lld:lifeskim |
| pubmed-article:6815691 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6815691 | pubmed:dateCreated | 1983-1-19 | lld:pubmed |
| pubmed-article:6815691 | pubmed:abstractText | A previously reported method for measuring tricyclic antidepressants (TCA) in plasma was modified to measure TCA, specifically amitriptyline (AMI) and nortriptyline (NOR) in rat brain tissue. Brains obtained from drug-free and AMI-treated rats were extracted and assayed using a Waters high-performance liquid chromatograph. Drug-free brain tissue contained no substances which interfered with the assay of these TCAs. Drug recovery averaged 90 +/- 3.4% (mean +/- SEM). Seven intra-run assays of a spiked brain tissue sample yielded coefficients of variation of 2.7% for AMI and 1.8% for NOR. Seven inter-run assays of the same sample varied 4.2% for AMI and 3.5% for NOR. Five separate assays of a brain homogenate sample spiked with 50 ng/ml of drug yielded values of 50 +/- 2.1 SEM ng/ml for AMI and 54 +/- 1.1 SEM ng/ml for NOR. Standard curves were linear when constructed from samples in a concentration range of 250--3,000 ng/g wet weight tissue (r = 0.96, P less than 0.001). | lld:pubmed |
| pubmed-article:6815691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6815691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6815691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6815691 | pubmed:issn | 0033-3158 | lld:pubmed |
| pubmed-article:6815691 | pubmed:author | pubmed-author:PreskornS HSH | lld:pubmed |
| pubmed-article:6815691 | pubmed:author | pubmed-author:GlotzbachR... | lld:pubmed |
| pubmed-article:6815691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6815691 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:6815691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6815691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6815691 | pubmed:pagination | 23-4 | lld:pubmed |
| pubmed-article:6815691 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:meshHeading | pubmed-meshheading:6815691-... | lld:pubmed |
| pubmed-article:6815691 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6815691 | pubmed:articleTitle | A liquid chromatographic method for quantitating amitriptyline in brain tissue. | lld:pubmed |
| pubmed-article:6815691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6815691 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
