| pubmed-article:6806671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C1420192 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C1536991 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:6806671 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:6806671 | pubmed:issue | 5872 | lld:pubmed |
| pubmed-article:6806671 | pubmed:dateCreated | 1982-8-26 | lld:pubmed |
| pubmed-article:6806671 | pubmed:abstractText | Germinal centres are histologically defined aggregates of blast cells that occur in B-cell areas of lymphoid tissues after antigenic stimulation. They are believed to be associated with the development of B-cell memory and plasma cell (especially secondary, IgG and IgA) responses. Recent studies of murine lymphoid tissues have defined cell-surface markers that distinguish germinal centre B cells from other mature B cells, permitting their identification and characterization in cell suspensions. Here we have used these markers to define and study germinal centre cells in lympho nodes, and have found that they constitute a unique population of B cells which (1) arises in response to antigenic stimulation, (2) contains nearly all of the demonstrably antigen-specific B cells in the stimulated organ, (3) bears surface IgM after primary stimulation and (4) as a population, demonstrates isotype switching to a predominant population, demonstrates isotype switching to a predominant surface IgG phenotype after secondary stimulation with specific surface IgG phenotype after secondary stimulation with specific antigen. These findings demonstrate that germinal centres are a major site of proliferation and differentiation of antigen-specific B cells in vivo, and suggest that the germinal centre microenvironment may have an important role in heavy chain class switching during B-cell responses. | lld:pubmed |
| pubmed-article:6806671 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6806671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6806671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6806671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6806671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6806671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6806671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6806671 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6806671 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6806671 | pubmed:author | pubmed-author:ButcherE CEC | lld:pubmed |
| pubmed-article:6806671 | pubmed:author | pubmed-author:KraalGG | lld:pubmed |
| pubmed-article:6806671 | pubmed:author | pubmed-author:WeissmanI LIL | lld:pubmed |
| pubmed-article:6806671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6806671 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:6806671 | pubmed:volume | 298 | lld:pubmed |
| pubmed-article:6806671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6806671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6806671 | pubmed:pagination | 377-9 | lld:pubmed |
| pubmed-article:6806671 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6806671 | pubmed:meshHeading | pubmed-meshheading:6806671-... | lld:pubmed |
| pubmed-article:6806671 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6806671 | pubmed:articleTitle | Germinal centre B cells: antigen specificity and changes in heavy chain class expression. | lld:pubmed |
| pubmed-article:6806671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6806671 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6806671 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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