| pubmed-article:6798005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:6798005 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:6798005 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:6798005 | pubmed:dateCreated | 1982-3-13 | lld:pubmed |
| pubmed-article:6798005 | pubmed:abstractText | Trimethylammonium methyl esters (DMS) of polyene macrolides are products of the methylation of native polyene antibiotics with dimethyl sulfate. We isolated individual components of the DMS-aureofacin complex and characterized their toxicity and activity to induce permeability changes in cell membranes. The DMS-aureofacin complex contained five components readily separated by thin-layer chromatography on polygram cellulose plates. DMS-Aureofacin A, a major component of the complex (90%), showed poor selective toxicity between yeast cells and mammalian cells grown in culture. DMS-Aureofacin B (6%) and DMS-aureofacin E (4%) exhibited very high biological activities and differed qualitatively in selective toxicity. DMS-Aureofacin B was much more active for mammalian cells than for yeast cells. In contrast, DMS-aureofacin E was much more active for yeast cells than for mammalian cells. DMS-Aureofacin C and D were present in the complex in only minute quantities which did not permit their biological characterization. | lld:pubmed |
| pubmed-article:6798005 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6798005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6798005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6798005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6798005 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6798005 | pubmed:issn | 0021-8820 | lld:pubmed |
| pubmed-article:6798005 | pubmed:author | pubmed-author:BorowskiEE | lld:pubmed |
| pubmed-article:6798005 | pubmed:author | pubmed-author:JenkinH MHM | lld:pubmed |
| pubmed-article:6798005 | pubmed:author | pubmed-author:MalewiczBB | lld:pubmed |
| pubmed-article:6798005 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6798005 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:6798005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6798005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6798005 | pubmed:pagination | 1486-91 | lld:pubmed |
| pubmed-article:6798005 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:meshHeading | pubmed-meshheading:6798005-... | lld:pubmed |
| pubmed-article:6798005 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6798005 | pubmed:articleTitle | Differential selective toxicity of DMS-aureofacin components. | lld:pubmed |
| pubmed-article:6798005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6798005 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6798005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6798005 | lld:pubmed |
