| pubmed-article:6777220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0012568 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C0017932 | lld:lifeskim |
| pubmed-article:6777220 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6777220 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:6777220 | pubmed:dateCreated | 1981-2-26 | lld:pubmed |
| pubmed-article:6777220 | pubmed:abstractText | The effect of insulin on glycogen synthase activity in human diploid fibroblasts has been studied. As little as 2 X 10(-10) M insulin increased the glycogen synthase / activity without changing the total activity. Stimulation occurred within 5 min and became maximal in 30 min. A half-maximal increase of / activity was achieved at 3 X 10(-9) M insulin. Glucose starvation increased the magnitude of response of glycogen synthase to insulin but did not change the insulin concentration necessary to give a half-maximal stimulation. Glucose increased the basal level of / activity in human diploid fibroblasts; the effect of insulin was additive. During in vitro senescence the total glycogen synthase activity declined, but the concentration of insulin that produced a half-maximal stimulation remained unchanged. These data indicate that regulation of glycogen synthase activity in human diploid fibroblasts is responsive to physiologic insulin levels and that the system provides a useful model for the in vitro study of insulin sensitivity. | lld:pubmed |
| pubmed-article:6777220 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6777220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6777220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6777220 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6777220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6777220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6777220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6777220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6777220 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6777220 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:LarnerJJ | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:HidakaHH | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:BennettP HPH | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:CraigJ WJW | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:HowardB VBV | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:FieldsR MRM | lld:pubmed |
| pubmed-article:6777220 | pubmed:author | pubmed-author:KosmakosF CFC | lld:pubmed |
| pubmed-article:6777220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6777220 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:6777220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6777220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6777220 | pubmed:pagination | 806-10 | lld:pubmed |
| pubmed-article:6777220 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:meshHeading | pubmed-meshheading:6777220-... | lld:pubmed |
| pubmed-article:6777220 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6777220 | pubmed:articleTitle | Insulin stimulation of glycogen synthase in cultured human diploid fibroblasts. | lld:pubmed |
| pubmed-article:6777220 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6777220 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6777220 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6777220 | lld:pubmed |
