| pubmed-article:6774019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0026912 | lld:lifeskim |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:6774019 | lifeskim:mentions | umls-concept:C0038857 | lld:lifeskim |
| pubmed-article:6774019 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6774019 | pubmed:dateCreated | 1980-11-20 | lld:pubmed |
| pubmed-article:6774019 | pubmed:abstractText | Human peripheral blood mononuclear cell (MN) proliferation and lymphokine production induced by mitogen could be inhibited by heat killed whole mycobacteria. The inhibition was induced by a wide variety of mycobacteri but not by other Gram-positive or Gram-negative organisms or by latex particles. Proliferation and lymphokine production by adherent cell-depleted lymphocytes was not inhibited by these organisms. Adherent cells treated with mycobacteria had the ability to inhibit lymphocyte blastogenesis when co-cultured with the lymphocytes. the inhibitory effect of these adherent cells was due to the release of a heat stable, nondialyzable suppressor cells. These latter cells, which were T gamma cells, could inhibit the blastogenic ability of normal lymphocytes activated by mitogens. The results suggest that in situations of high mycobacterial load, adherent cells are activted to release a suppressor factor that will activate lymphocytes to become suppressor cells. This mechanism may explain the anergy associated with lepromatous leprosy or advanced tuberculosis. | lld:pubmed |
| pubmed-article:6774019 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6774019 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6774019 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6774019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6774019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6774019 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6774019 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6774019 | pubmed:author | pubmed-author:RabsonA RAR | lld:pubmed |
| pubmed-article:6774019 | pubmed:author | pubmed-author:SherRR | lld:pubmed |
| pubmed-article:6774019 | pubmed:author | pubmed-author:WadeeA AAA | lld:pubmed |
| pubmed-article:6774019 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6774019 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:6774019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6774019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6774019 | pubmed:pagination | 1380-6 | lld:pubmed |
| pubmed-article:6774019 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:6774019 | pubmed:meshHeading | pubmed-meshheading:6774019-... | lld:pubmed |
| pubmed-article:6774019 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6774019 | pubmed:articleTitle | Production of a suppressor factor by human adherent cells treated with mycobacteria. | lld:pubmed |
| pubmed-article:6774019 | pubmed:publicationType | Journal Article | lld:pubmed |
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