| pubmed-article:6769117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6769117 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:6769117 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6769117 | lifeskim:mentions | umls-concept:C0598665 | lld:lifeskim |
| pubmed-article:6769117 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:6769117 | lifeskim:mentions | umls-concept:C2828389 | lld:lifeskim |
| pubmed-article:6769117 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6769117 | pubmed:dateCreated | 1980-7-12 | lld:pubmed |
| pubmed-article:6769117 | pubmed:abstractText | The nuclear RNA from a large variety of kappa-producing plasmacytomas was size fractionated and analyzed with a series of cloned probes representing sequences encoding variable (V), joining (J), and constant (C) regions and selected intervening sequences. All of the plasmacytomas produce a nuclear RNA component that contains V kappa and C kappa sequences as well as the intervening sequence between J kappa and C kappa, and that has a distinctive size depending on which of the four J kappa segments is expressed (i.e., is present in the secreted kappa chain). These RNAs are the precursors of kappa mRNAs, which are transcribed from productively rearranged C kappa genes. Half of the plasmacytomas examined produce, in addition to a kappa mRNA precursor, a discrete component of about 8.4 kilobases that contains C kappa and upstream flanking sequences but lacks the expressed V region sequence. The ability to produce this component is always associated with the persistence in the tumor genome of an unrearranged (germline) J kappa-C kappa region. In tumors rearranged at both kappa loci the nonproductive allele is either transcriptionally silent or, in a minority of cases, transcribed and processed into a "fragment" mRNA lacking V region sequences. These results reveal that allelic exclusion can be effected at several levels of gene expression. They also provide some insight into the relative contributions of the V and C gene elements to this expression. | lld:pubmed |
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| pubmed-article:6769117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6769117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6769117 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6769117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6769117 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6769117 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:LederPP | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:TonegawaSS | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:MatthyssensGG | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:PerryR PRP | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:WeigertMM | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:SeidmanJ GJG | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:KelleyD EDE | lld:pubmed |
| pubmed-article:6769117 | pubmed:author | pubmed-author:ColecloughCC | lld:pubmed |
| pubmed-article:6769117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6769117 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:6769117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6769117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6769117 | pubmed:pagination | 1937-41 | lld:pubmed |
| pubmed-article:6769117 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6769117 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6769117 | pubmed:articleTitle | Transcription of mouse kappa chain genes: implications for allelic exclusion. | lld:pubmed |
| pubmed-article:6769117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6769117 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6769117 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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