pubmed-article:6748640 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6748640 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
pubmed-article:6748640 | lifeskim:mentions | umls-concept:C0039601 | lld:lifeskim |
pubmed-article:6748640 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
pubmed-article:6748640 | lifeskim:mentions | umls-concept:C1882727 | lld:lifeskim |
pubmed-article:6748640 | lifeskim:mentions | umls-concept:C0886518 | lld:lifeskim |
pubmed-article:6748640 | pubmed:issue | 6A | lld:pubmed |
pubmed-article:6748640 | pubmed:dateCreated | 1984-8-29 | lld:pubmed |
pubmed-article:6748640 | pubmed:abstractText | 5 alpha-Reduction of testosterone was observed in lung cells obtained by bronchoalveolar lavage (greater than 95% macrophages) from the rats. This activity was inhibited by progesterone and corticosterone. Production of 17 beta-hydroxy-5 alpha-androstane-3-one and 5 alpha-androstane-3 alpha, 17 beta-diol from testosterone was higher in rat pulmonary alveolar macrophages than by the 800 g supernatant fraction of whole lung homogenate from the same animals. Alveolar macrophages from rats treated with the 5 alpha-reductase inhibitor 17 beta-N,N-diethylcarbamoyl-4-aza-4-methyl-5 alpha-androstane-3-one (5 mg/100 g b.w., s.c.) showed decreased metabolism of testosterone to 17 beta-hydroxy-5 alpha-androstane-3-one and 5 alpha-androstane-3 alpha, 17 beta-diol 4 h after treatment. This metabolism was also decreased in alveolar macrophages from rats exposed to potassium dichromate by intratracheal instillation. When bovine alveolar macrophages were incubated with potassium dichromate, 5 alpha-reduction of testosterone decreased significantly. The function of steroid 5 alpha-reduction in alveolar macrophages is currently not known. | lld:pubmed |
pubmed-article:6748640 | pubmed:language | eng | lld:pubmed |
pubmed-article:6748640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6748640 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6748640 | pubmed:month | Jun | lld:pubmed |
pubmed-article:6748640 | pubmed:issn | 0022-4731 | lld:pubmed |
pubmed-article:6748640 | pubmed:author | pubmed-author:Eik-NesK BKB | lld:pubmed |
pubmed-article:6748640 | pubmed:author | pubmed-author:LofthusRR | lld:pubmed |
pubmed-article:6748640 | pubmed:author | pubmed-author:MarthinsenA... | lld:pubmed |
pubmed-article:6748640 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6748640 | pubmed:volume | 20 | lld:pubmed |
pubmed-article:6748640 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6748640 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6748640 | pubmed:pagination | 1243-6 | lld:pubmed |
pubmed-article:6748640 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:6748640 | pubmed:year | 1984 | lld:pubmed |
pubmed-article:6748640 | pubmed:articleTitle | Metabolism of testosterone to 17 beta-hydroxy-5 alpha-androstane-3-one and 5 alpha-androstane-3 alpha, 17 beta-diol in alveolar macrophages from rat lung. | lld:pubmed |
pubmed-article:6748640 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6748640 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:6748640 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |