| pubmed-article:6747535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6747535 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:6747535 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:6747535 | lifeskim:mentions | umls-concept:C0997770 | lld:lifeskim |
| pubmed-article:6747535 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:6747535 | lifeskim:mentions | umls-concept:C0078437 | lld:lifeskim |
| pubmed-article:6747535 | pubmed:dateCreated | 1984-9-17 | lld:pubmed |
| pubmed-article:6747535 | pubmed:abstractText | The anticalmodulin drug, W-7 [N-(6 aminohexyl)-5-chloro-1-naphthalenesulphonamide] specifically inhibits the voltage-dependent Ca-current of Paramecium as well as the behavioural consequence of Ca2+ influx, backward swimming. The dechlorinated analogue, W-5, is four to five times less effective. Analysis of membrane currents under voltage clamp shows that W-7 not only reversibly inhibits the voltage-dependent Ca-current but also shifts the voltage sensitivity of this Ca-current towards less negative voltages in a concentration-dependent manner. We suggest that Paramecium can be used as a system to screen behaviourally for other Ca-channel blockers as well as to study the mechanism of action of these drugs. | lld:pubmed |
| pubmed-article:6747535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6747535 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6747535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6747535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6747535 | pubmed:month | May | lld:pubmed |
| pubmed-article:6747535 | pubmed:issn | 0022-0949 | lld:pubmed |
| pubmed-article:6747535 | pubmed:author | pubmed-author:KunoKK | lld:pubmed |
| pubmed-article:6747535 | pubmed:author | pubmed-author:HennesseyT... | lld:pubmed |
| pubmed-article:6747535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6747535 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:6747535 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6747535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6747535 | pubmed:pagination | 169-81 | lld:pubmed |
| pubmed-article:6747535 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:meshHeading | pubmed-meshheading:6747535-... | lld:pubmed |
| pubmed-article:6747535 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6747535 | pubmed:articleTitle | An anticalmodulin drug, W-7, inhibits the voltage-dependent calcium current in Paramecium caudatum. | lld:pubmed |
| pubmed-article:6747535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6747535 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6747535 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6747535 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6747535 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6747535 | lld:pubmed |
