| pubmed-article:6745927 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6745927 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:6745927 | lifeskim:mentions | umls-concept:C1707427 | lld:lifeskim |
| pubmed-article:6745927 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:6745927 | lifeskim:mentions | umls-concept:C1522384 | lld:lifeskim |
| pubmed-article:6745927 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6745927 | pubmed:dateCreated | 1984-8-24 | lld:pubmed |
| pubmed-article:6745927 | pubmed:abstractText | Nine XX true hermaphrodites and two XX males were discovered in a family of American cocker spaniels. The true hermaphrodites were partially-masculinized females with ovotestes; the XX males had malformed male external genitalia and cryptorchid aspermatogenic testes. Wolffian and Mullerian duct derivatives were present in both true hermaphrodites and XX males. All four sires of sex-reversed dogs were normal XY males; five of the dams were anatomically normal females and one was an XX true hermaphrodite. A second true hermaphrodite reproduced as a female, producing anatomically normal offspring. All matings that produced sex-reversed offspring were consanguineous. Matings of the parents of sex-reversed cocker spaniels to normal beagles with no family history of intersexuality produced only normal offspring. Examination of G-banded karyotypes of the affected animals, their parents, and siblings, revealed no structural anomalies of the chromosomes that were consistently associated with sex-reversal. In assays for serologically-detectable H-Y antigen, the group of XX true hermaphrodites and the group of XX males had mean levels of the antigen not significantly different from that in normal male controls. Female parents of sex-reversed dogs and some of their female siblings were typed H-Y antigen positive, but the mean level of the antigen in this group was less than that of normal male controls. It is proposed that XX sex reversal in cocker spaniels is due to a mutant gene which when homozygous in females, results in a level of H-Y antigen similar to that found in normal males and the gonads develop as ovotestes or testes. When the gene is heterozygous in females, the level of serologically-detectable H-Y antigen is lower than that found in normal males and the gonads develop as normal ovaries. The persistence of Mullerian structures in the presence of testicular tissue suggests that Mullerian inhibiting substance is deficient or ineffective in its action in this condition. | lld:pubmed |
| pubmed-article:6745927 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6745927 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6745927 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6745927 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6745927 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6745927 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6745927 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6745927 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6745927 | pubmed:issn | 0340-6717 | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:MoorheadP SPS | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:PAIK NKN | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:WachtelS SSS | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:PattersonD... | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:HaskinsM EME | lld:pubmed |
| pubmed-article:6745927 | pubmed:author | pubmed-author:SeldenJ RJR | lld:pubmed |
| pubmed-article:6745927 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6745927 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:6745927 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6745927 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6745927 | pubmed:pagination | 62-9 | lld:pubmed |
| pubmed-article:6745927 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:6745927 | pubmed:meshHeading | pubmed-meshheading:6745927-... | lld:pubmed |
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| pubmed-article:6745927 | pubmed:meshHeading | pubmed-meshheading:6745927-... | lld:pubmed |
| pubmed-article:6745927 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6745927 | pubmed:articleTitle | Inherited XX sex reversal in the cocker spaniel dog. | lld:pubmed |
| pubmed-article:6745927 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6745927 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6745927 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
