| pubmed-article:673838 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:673838 | lifeskim:mentions | umls-concept:C0032550 | lld:lifeskim |
| pubmed-article:673838 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:673838 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:673838 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:673838 | lifeskim:mentions | umls-concept:C0071370 | lld:lifeskim |
| pubmed-article:673838 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:673838 | pubmed:dateCreated | 1978-9-30 | lld:pubmed |
| pubmed-article:673838 | pubmed:abstractText | 2'-Deoxy-2'-fluoroadenosine was chemically transformed to its 5'-diphosphate and polymerized with polynucleotide phosphorylase to give poly(2'-deoxy-2'-fluoroadenylic acid) [poly(Af)]. Polymerization proceeded smoothly as in the case of poly(A) and the yield of the polymerization was 55%. The UV absorption spectra of poly(Af) closely resembled those of poly(A) and the hypochromicity was 32% at pH 7.0. The CD profile at 25 degrees and neutrality showed similar pattern to that of other poly(2'-deoxy-2'-halogenoadenylic acids) with somewhat larger [theta] values both in the positive and negative maxima. Acid titration of poly(Af) showed a transition point at pH 5.2 and the Tm of the acid form was 37 degrees which was significantly lower than that of poly(A), but similar to that of poly(2'-azido-2'-deoxyadenylic acid). Poly(Af) formed 1:1 and 1:2 complexes with poly-(U) having Tm of 49 degrees and 62 degrees at 0.04M and 0.15M Na(+) concentration, respectively. Poly(Af) also formed a 1:2 complex with poly(I) and its Tm was 36 degrees at 0.05M Na(+) concentration. These data showed that poly(Af) has rather similar properties to those of poly(A), but not to poly(dA). | lld:pubmed |
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| pubmed-article:673838 | pubmed:language | eng | lld:pubmed |
| pubmed-article:673838 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:673838 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:673838 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:673838 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:673838 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:673838 | pubmed:author | pubmed-author:IkeharaMM | lld:pubmed |
| pubmed-article:673838 | pubmed:author | pubmed-author:FukuiTT | lld:pubmed |
| pubmed-article:673838 | pubmed:author | pubmed-author:KakiuchiNN | lld:pubmed |
| pubmed-article:673838 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:673838 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:673838 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:673838 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:673838 | pubmed:pagination | 1877-87 | lld:pubmed |
| pubmed-article:673838 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-C... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-S... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-S... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-N... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-P... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-P... | lld:pubmed |
| pubmed-article:673838 | pubmed:meshHeading | pubmed-meshheading:673838-P... | lld:pubmed |
| pubmed-article:673838 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:673838 | pubmed:articleTitle | Polynucleotides. LII. Synthesis and properties of poly(2'-deoxy-2'-fluoroadenylic acid). | lld:pubmed |
| pubmed-article:673838 | pubmed:publicationType | Journal Article | lld:pubmed |
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