| pubmed-article:6699091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C1515681 | lld:lifeskim |
| pubmed-article:6699091 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:6699091 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6699091 | pubmed:dateCreated | 1984-4-24 | lld:pubmed |
| pubmed-article:6699091 | pubmed:abstractText | Quiescent human peripheral blood lymphocytes have been shown to maintain a relatively constant intracellular pH of 7.0-7.2 over an extracellular pH range of 6.9-7.4. Two methods of measuring intracellular pH were used in these studies, 19F nuclear magnetic resonance and [14C]5,5-dimethyloxazolidine-2,4-dione (DMO) equilibrium distributions. When ATP levels were decreased in these cells, actively maintained pH regulation was abolished and cells exhibited a constant pH gradient of 0.2 pH unit (acid inside relative to outside). Possible mechanisms for pH regulation are discussed. The effects of the Na+ and K+ composition of the medium on pH regulation showed no correlation with their effects on mitogen-induced proliferative response, which we have previously determined (Deutsch, C., and M. Price, 1982, J. Cell. Physiol., 111:73-79). In low-Na+ mannitol medium, pH regulation was similar to that observed for lymphocytes in normal medium, whereas mitogen-induced proliferation was severely inhibited in low-Na+ mannitol. In contrast, high-K+, low Na+ medium caused loss of pH homeostasis, whereas it restored the proliferative response. Loss of pH homeostasis was also observed on prolonged exposure of lymphocytes to mitogen (greater than 6 h in culture). However, mitogen stimulation led to little or no change in intracellular pH in the first few hours of cell culture. Therefore, a shift in intracellular pH is not a necessary or general event in mitogen-stimulated proliferation of lymphocytes. | lld:pubmed |
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| pubmed-article:6699091 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6699091 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6699091 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6699091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6699091 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6699091 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:6699091 | pubmed:author | pubmed-author:DeutschCC | lld:pubmed |
| pubmed-article:6699091 | pubmed:author | pubmed-author:TaylorJ SJS | lld:pubmed |
| pubmed-article:6699091 | pubmed:author | pubmed-author:PriceMM | lld:pubmed |
| pubmed-article:6699091 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6699091 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:6699091 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6699091 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6699091 | pubmed:pagination | 885-93 | lld:pubmed |
| pubmed-article:6699091 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6699091 | pubmed:meshHeading | pubmed-meshheading:6699091-... | lld:pubmed |
| pubmed-article:6699091 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6699091 | pubmed:articleTitle | pH homeostasis in human lymphocytes: modulation by ions and mitogen. | lld:pubmed |
| pubmed-article:6699091 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6699091 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6699091 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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