| pubmed-article:6698661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6698661 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:6698661 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:6698661 | lifeskim:mentions | umls-concept:C0016301 | lld:lifeskim |
| pubmed-article:6698661 | lifeskim:mentions | umls-concept:C0032950 | lld:lifeskim |
| pubmed-article:6698661 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:6698661 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6698661 | pubmed:dateCreated | 1984-4-4 | lld:pubmed |
| pubmed-article:6698661 | pubmed:abstractText | The pharmacokinetics of fluocortolone and of prednisolone were examined following a single intravenous injection of 5 mg and oral administrations of 10 and 20 mg to five healthy male volunteers. After intravenous injection the plasma levels of fluocortolone decreased biexponentially with half-lives of 9 +/- 5 min and 1.3 +/- 0.3 h. Total plasma clearance of fluocortolone was calculated to be 7.0 +/- 1.5 ml/min/kg. Oral administrations of fluocortolone revealed maximum plasma levels of 86 +/- 12 ng/ml (10-mg dose) and 174 +/- 34 ng/ml (20-mg dose) after 1.4 +/- 0.2 h. Intravenously administered prednisolone was rapidly distributed (t 1/2 alpha = 5 +/- 3 min) but more slowly eliminated from plasma than fluocortolone (t1/2 beta = 3.1 +/- 0.8 h). Correspondingly a total plasma clearance of 2.2 +/- 0.2 ml/min/kg was calculated. Oral administrations revealed maximum prednisolone plasma levels of 172 +/- 25 ng/ml (10-mg dose) and 278 ng/ml (20-mg dose) after 1.6 +/- 0.7 h. The absolute bioavailability of both corticosteroids was higher than 80% and independent of both dose levels investigated. | lld:pubmed |
| pubmed-article:6698661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6698661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6698661 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6698661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6698661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6698661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6698661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6698661 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6698661 | pubmed:issn | 0174-4879 | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:VecseiPP | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:WendtHH | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:HaackDD | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:NieuweboerBB | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:TäuberUU | lld:pubmed |
| pubmed-article:6698661 | pubmed:author | pubmed-author:KlossGG | lld:pubmed |
| pubmed-article:6698661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6698661 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:6698661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6698661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6698661 | pubmed:pagination | 48-55 | lld:pubmed |
| pubmed-article:6698661 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:meshHeading | pubmed-meshheading:6698661-... | lld:pubmed |
| pubmed-article:6698661 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6698661 | pubmed:articleTitle | The pharmacokinetics of fluocortolone and prednisolone after intravenous and oral administration. | lld:pubmed |
| pubmed-article:6698661 | pubmed:publicationType | Journal Article | lld:pubmed |
