| pubmed-article:6697969 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C0040160 | lld:lifeskim |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C0040135 | lld:lifeskim |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C0025723 | lld:lifeskim |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6697969 | lifeskim:mentions | umls-concept:C0312431 | lld:lifeskim |
| pubmed-article:6697969 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6697969 | pubmed:dateCreated | 1984-3-30 | lld:pubmed |
| pubmed-article:6697969 | pubmed:abstractText | Synthesis of phosphatidylcholine (PC) by S-adenosylmethionine-dependent methylation of phosphatidylethanolamine has previously been associated with receptor-mediated histamine and pituitary hormone secretion. We investigated stimulation of phospholipid methylation by TSH and its possible role in thyroid hormone secretion. Rat hemithyroids were incubated in Krebs-Henseleit-glucose-BSA buffer and the effect of various treatments on the incorporation of [3H-methyl]L-methionine into PC and T4/T3 secretion was studied. TSH treatment elevated thyroid phosphatidylethanolamine methyltransferase activity, the incorporation of [3H-methyl]methionine into PC, and T4/T3 secretion. The increase in PC synthesis was linear up to 6 h in a dose-dependent fashion (half-maximal stimulation at 2.5 micrograms TSH/ml). Stimulation required protein synthesis, because cycloheximide inhibited the increase in PC synthesis by 77%. Inhibitors of phospholipid methylation (100 microM adenosine + 10 microM L-homocysteine thiolactone + 10 microM erythro-9[2-hydroxy-3-nonyl]adenine) significantly decreased TSH-stimulation of phospholipid methylation but not T3/T4 secretion. In conclusion, stimulation of thyroid phospholipid methylation by TSH is not required for stimulated secretion of thyroid hormones. | lld:pubmed |
| pubmed-article:6697969 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6697969 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6697969 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6697969 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6697969 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:6697969 | pubmed:author | pubmed-author:PrasadCC | lld:pubmed |
| pubmed-article:6697969 | pubmed:author | pubmed-author:EdwardsR MRM | lld:pubmed |
| pubmed-article:6697969 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6697969 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:6697969 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6697969 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6697969 | pubmed:pagination | 941-5 | lld:pubmed |
| pubmed-article:6697969 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:meshHeading | pubmed-meshheading:6697969-... | lld:pubmed |
| pubmed-article:6697969 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6697969 | pubmed:articleTitle | Stimulation of phospholipid methylation and thyroid hormone secretion by thyrotropin. | lld:pubmed |
| pubmed-article:6697969 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6697969 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6697969 | lld:pubmed |
