| pubmed-article:6694911 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:6694911 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:6694911 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6694911 | pubmed:dateCreated | 1984-3-23 | lld:pubmed |
| pubmed-article:6694911 | pubmed:abstractText | 5-Noncoding sequences have been tabulated for 211 messenger RNAs from higher eukaryotic cells. The 5'-proximal AUG triplet serves as the initiator codon in 95% of the mRNAs examined. The most conspicuous conserved feature is the presence of a purine (most often A) three nucleotides upstream from the AUG initiator codon; only 6 of the mRNAs in the survey have a pyrimidine in that position. There is a predominance of C in positions -1, -2, -4 and -5, just upstream from the initiator codon. The sequence CCAGCCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites. The extent to which the ribosome binding site in a given mRNA matches the -1 to -5 consensus sequence varies: more than half of the mRNAs in the tabulation have 3 or 4 nucleotides in common with the CCACC consensus, but only ten mRNAs conform perfectly. | lld:pubmed |
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