| pubmed-article:6694163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6694163 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:6694163 | lifeskim:mentions | umls-concept:C0001629 | lld:lifeskim |
| pubmed-article:6694163 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6694163 | lifeskim:mentions | umls-concept:C1527121 | lld:lifeskim |
| pubmed-article:6694163 | lifeskim:mentions | umls-concept:C1512628 | lld:lifeskim |
| pubmed-article:6694163 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6694163 | pubmed:dateCreated | 1984-3-23 | lld:pubmed |
| pubmed-article:6694163 | pubmed:abstractText | Fourteen 125I-labeled aralkylguanidines were synthesized and evaluated as potential imaging agents for the adrenal medullae and tumors of adrenomedullary origin. These guanidines are radiotracer analogues of guanethidine, an antihypertensive agent thought to mediate neuron blockade by uptake into adrenergic nerves. Dog adrenal medullae were used as a model to test radiotracer affinity for catecholamine storage tissue. Tissue distribution studies revealed that a number of radioiodinated guanidines showed pronounced localization in the adrenal medullae following intravenous injection, in certain cases exceeding that of either (-)-[3H]norepinephrine or [14C]guanethidine. (m-[125I]Iodobenzyl)guanidine (m-IBG, 2b) gave the best combination of high concentration and selectivity. The low adrenomedullary affinity observed with [14C]guanidine and m-[125I]iodobenzylamine demonstrates the uniqueness of the aralkylguanidine structure. Preliminary evidence suggests that 2b is a storage analogue of norepinephrine. [125I]2a is now being used clinically in imaging and radiotherapy of catecholamine tumors, such as pheochromocytoma. | lld:pubmed |
| pubmed-article:6694163 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6694163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6694163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6694163 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6694163 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:6694163 | pubmed:author | pubmed-author:BrownL ELE | lld:pubmed |
| pubmed-article:6694163 | pubmed:author | pubmed-author:WielandD MDM | lld:pubmed |
| pubmed-article:6694163 | pubmed:author | pubmed-author:WuJ LJL | lld:pubmed |
| pubmed-article:6694163 | pubmed:author | pubmed-author:MangnerT JTJ | lld:pubmed |
| pubmed-article:6694163 | pubmed:author | pubmed-author:InbasekaranM... | lld:pubmed |
| pubmed-article:6694163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6694163 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:6694163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6694163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6694163 | pubmed:pagination | 149-55 | lld:pubmed |
| pubmed-article:6694163 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
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| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:meshHeading | pubmed-meshheading:6694163-... | lld:pubmed |
| pubmed-article:6694163 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6694163 | pubmed:articleTitle | Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidines. | lld:pubmed |
| pubmed-article:6694163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6694163 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6694163 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6694163 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:6694163 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6694163 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6694163 | lld:pubmed |
