| pubmed-article:6683881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C0024399 | lld:lifeskim |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C0524800 | lld:lifeskim |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C0058464 | lld:lifeskim |
| pubmed-article:6683881 | lifeskim:mentions | umls-concept:C0525093 | lld:lifeskim |
| pubmed-article:6683881 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6683881 | pubmed:dateCreated | 1983-9-23 | lld:pubmed |
| pubmed-article:6683881 | pubmed:abstractText | The pulmonary and dermal effects of exposure to Na2PtCl6 were investigated in cynomolgus monkeys (Macaca fascicularis) exposed by the nose-only inhalation and percutaneous routes. Separate inhalation exposures were performed in monkeys at 200 micrograms/m3 and 2 mg/m3 (4 hr/day, biweekly for 12 weeks), while another group of monkeys was percutaneously exposed biweekly by an open patch method. After a 2-week refractory period, serial Na2PtCl6 bronchoprovocation challenges and intradermal Na2PtCl6 sensitivity evaluations were performed. Na2PtCl6 bronchoprovocation in naive control monkeys yielded significant impairments in post-challenge pulmonary mechanics and ventilatory function. These results indicate a pharmacologic or irritant-mediated bronchoconstriction mechanism for acute exposure to this compound. When the post-challenge pulmonary function of animals exposed for the 12-week exposure regimen (across treatments) was compared to pulmonary deficits observed in control animals upon challenge, significantly greater pulmonary deficits were seen in animals exposed at the 200 micrograms/m3 concentration. Exposure at this concentration yielded significant changes in post-challenge average pulmonary flow resistance (RL) and forced expiratory volume in 0.5 sec corrected for vital capacity (FEV0.5/FVC) when compared to control monkey responses. Animals exposed by the percutaneous route or at 2 mg/m3 showed no significant post-challenge pulmonary deficits when compared to control animals. Intradermal Na2PtCl6 sensitivity was found not to be exposure related in the conditions of this experiment. | lld:pubmed |
| pubmed-article:6683881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6683881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6683881 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6683881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6683881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6683881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6683881 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6683881 | pubmed:issn | 0041-008X | lld:pubmed |
| pubmed-article:6683881 | pubmed:author | pubmed-author:SmithR JRJ | lld:pubmed |
| pubmed-article:6683881 | pubmed:author | pubmed-author:LewisT RTR | lld:pubmed |
| pubmed-article:6683881 | pubmed:author | pubmed-author:BernsteinI... | lld:pubmed |
| pubmed-article:6683881 | pubmed:author | pubmed-author:BiaginiR ERE | lld:pubmed |
| pubmed-article:6683881 | pubmed:author | pubmed-author:MoormanW JWJ | lld:pubmed |
| pubmed-article:6683881 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6683881 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:6683881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6683881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6683881 | pubmed:pagination | 377-84 | lld:pubmed |
| pubmed-article:6683881 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:meshHeading | pubmed-meshheading:6683881-... | lld:pubmed |
| pubmed-article:6683881 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6683881 | pubmed:articleTitle | Pulmonary hyperreactivity in cynomolgus monkeys (Macaca fascicularis) from nose-only inhalation exposure to disodium hexachloroplatinate, Na2PtCl6. | lld:pubmed |
| pubmed-article:6683881 | pubmed:publicationType | Journal Article | lld:pubmed |
