| pubmed-article:6662199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6662199 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6662199 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:6662199 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:6662199 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6662199 | lifeskim:mentions | umls-concept:C0596795 | lld:lifeskim |
| pubmed-article:6662199 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:6662199 | pubmed:dateCreated | 1984-3-2 | lld:pubmed |
| pubmed-article:6662199 | pubmed:abstractText | Application of PAF-acether (platelet-activating factor) (final concentration 1-20 nM) to the microcirculation of the hamster cheek pouch resulted in dose-dependent vasoconstriction and an increase in macromolecular permeability, as assessed by leakage of intravascular fluorescein-labelled dextran (Mw 150 000). An increase in adhering leukocytes in venules was only seen with 20 nM PAF-acether. Animals made neutropenic by treatment with antineutrophil serum raised in rabbits showed a reduced leakage response to 20 nM PAF-acether, whereas the leakage induced with 5 nM PAF-acether was unaffected. This indicates that the increase in vascular permeability induced by PAF-acether occurs both as a presumably direct effect independent of polymorphonuclear leukocytes (PMNL), and via an indirect PMNL-dependent mechanism. Intravenous administration of PAF-acether (10 micrograms/kg body weight) to hamsters resulted in rapid and transient thrombocytopenia and leukopenia whereas 1 microgram/kg only affected the leukocytes. These potent microvascular effects of PAF-acether support its proposed role as a mediator of allergic and inflammatory reactions. | lld:pubmed |
| pubmed-article:6662199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6662199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6662199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6662199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6662199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6662199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6662199 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6662199 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:6662199 | pubmed:author | pubmed-author:SmedegårdGG | lld:pubmed |
| pubmed-article:6662199 | pubmed:author | pubmed-author:BjörkJJ | lld:pubmed |
| pubmed-article:6662199 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6662199 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:6662199 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:6662199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6662199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6662199 | pubmed:pagination | 87-94 | lld:pubmed |
| pubmed-article:6662199 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:meshHeading | pubmed-meshheading:6662199-... | lld:pubmed |
| pubmed-article:6662199 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6662199 | pubmed:articleTitle | Acute microvascular effects of PAF-acether, as studied by intravital microscopy. | lld:pubmed |
| pubmed-article:6662199 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6662199 | lld:pubmed |
