Linked Life Data

6655049

Source:http://linkedlifedata.com/resource/pubmed/id/6655049

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SubjectPredicateObjectContext
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pubmed-article:6655049pubmed:abstractTextCerebrospinal fluid (CSF) was removed from guinea pigs with chronic relapsing experimental allergic encephalomyelitis (CR-EAE) and control inoculated animals by puncture of the cisterna magna. The fluid from 7/8 animals in relapse and 2/4 animals in remission phases of CR-EAE was found to promote the migration of peripheral blood monocytes through a 5-micron pore diameter polycarbonate membrane filter. Monocytes were also found to orient towards the migration-stimulating CSF in a gradient formed between such fluid and CSF derived from a control animal, thereby indicating the presence of a chemotactic factor. The factor responsible for promoting monocyte migration had a molecular weight of between 50 000 and 300 000 as defined by ultrafiltration. The results are discussed in relation to the known pathohistological features of the chronic relapsing disease.lld:pubmed
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pubmed-article:6655049pubmed:articleTitleChronic relapsing experimental allergic encephalomyelitis. The presence in the cerebrospinal fluid of factors chemotactic for monocytes.lld:pubmed
pubmed-article:6655049pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6655049pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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