| pubmed-article:6622110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C0220934 | lld:lifeskim |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:6622110 | lifeskim:mentions | umls-concept:C0336862 | lld:lifeskim |
| pubmed-article:6622110 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:6622110 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6622110 | pubmed:abstractText | Surface active aerosols were produced from aqueous dispersions of mixed lipids (CLL), extracted from bovine lung lavage. Particle size distributions were measured as a function of humidity for two types of aerosol generators: ultrasonic and jet. Lipid dispersions before aerosolization were prepared by sonication in an ice bath and by mechanical vortexing. Over a range of high humidity greater than 60-70%, ultrasonic nebulization gave CLL aerosols with mass median aerodynamic diameters (MMAD) of 1.4 +/- 0.1 micron, compatible with predicted alveolar deposition fractions of 0.2-0.3 according to current deposition models. For humidities of 30-95%, jet nebulization gave MMAD values of 0.4-0.5 micron, which have lower predicted alveolar deposition. The surface pressure-time (pi - t) adsorption characteristics at 35 +/- 2 degrees C of CLL dispersions prepared initially by vortexing or sonication were not significantly affected by ultrasonic nebulization over a 1-2 h time period. In addition, the dynamic surface tension lowering of both kinds of CLL dispersion was not affected by ultrasonic nebulization (minimum surface tension less than 1 dyne/cm at 37 degrees C and 100% humidity). Current interest in the treatment of the respiratory distress syndrome (RDS) with exogenous surfactant replacement has focused largely on the delivery of surfactant replacement has focused largely on h delivery of surfactants to infants by tracheal instillation at birth. However, the ability to form multi-component surfactant aerosols with appreciable alveolar deposition fractions and high surface activity may help to expand the utility of replacement therapy to patients with aerated lungs. | lld:pubmed |
| pubmed-article:6622110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6622110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6622110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6622110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6622110 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6622110 | pubmed:issn | 0031-3998 | lld:pubmed |
| pubmed-article:6622110 | pubmed:author | pubmed-author:McBrideJ TJT | lld:pubmed |
| pubmed-article:6622110 | pubmed:author | pubmed-author:NotterR HRH | lld:pubmed |
| pubmed-article:6622110 | pubmed:author | pubmed-author:MarksL BLB | lld:pubmed |
| pubmed-article:6622110 | pubmed:author | pubmed-author:OberdorsterGG | lld:pubmed |
| pubmed-article:6622110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6622110 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:6622110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6622110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6622110 | pubmed:pagination | 742-7 | lld:pubmed |
| pubmed-article:6622110 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:6622110 | pubmed:meshHeading | pubmed-meshheading:6622110-... | lld:pubmed |
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| pubmed-article:6622110 | pubmed:meshHeading | pubmed-meshheading:6622110-... | lld:pubmed |
| pubmed-article:6622110 | pubmed:meshHeading | pubmed-meshheading:6622110-... | lld:pubmed |
| pubmed-article:6622110 | pubmed:meshHeading | pubmed-meshheading:6622110-... | lld:pubmed |
| pubmed-article:6622110 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6622110 | pubmed:articleTitle | Ultrasonic and jet aerosolization of phospholipids and the effects on surface activity. | lld:pubmed |
| pubmed-article:6622110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6622110 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6622110 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6622110 | lld:pubmed |
