| pubmed-article:6609990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0019348 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:6609990 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:6609990 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6609990 | pubmed:dateCreated | 1984-7-18 | lld:pubmed |
| pubmed-article:6609990 | pubmed:abstractText | In contrast to general findings that mouse and human cytotoxic T lymphocytes (CTL) are restricted in cytotoxic activity by major histocompatibility complex (MHC) class I antigens, we previously found that some herpes simplex virus (HSV) type I-infected cells that shared no HLA class I antigens with the HSV-1-stimulated lymphocytes were lysed. In this study, we addressed the question of the role of HLA antigens in human T cell-mediated lysis of HSV-1-infected cells by generating clones of HSV-1-directed CTL from two HSV-1-seropositive individuals. CTL clones that lysed autologous HSV-1-infected lymphoblastoid cell lines (LCL), but not natural killer-sensitive K562 cells or uninfected or influenza virus-infected LCL, were tested for cytotoxicity against a panel of allogeneic HSV-1-infected LCL. Clone KL-35 from individual KL lysed only HSV-1-infected LCL sharing the HLA class II MB1 antigen with KL. With all four CTL clones isolated from individual PM, only HSV-1-infected LCL sharing DR1 with PM were lysed. Monoclonal antibody s3/4 (directed against MB1 ), but not TS1/16 or B33 .1 (directed against a DR framework determinant), blocked lysis of autologous HSV-1-infected cells by KL-35. In contrast, B33 .1, but not s3/4, blocked lysis of autologous HSV-1-infected cells by the PM CTL clones but not by KL-35. Together, these results indicate that our five human CTL clones which are directed against HSV-1-infected cells, and which are all OKT3+, OKT4+, OKT8-, are restricted in lytic activity by HLA class II MB and DR antigens. These results suggest that the HLA D region-encoded class II antigens may be important in the recognition and destruction of virus-infected cells by human CTL. | lld:pubmed |
| pubmed-article:6609990 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6609990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6609990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6609990 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6609990 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6609990 | pubmed:author | pubmed-author:YasukawaMM | lld:pubmed |
| pubmed-article:6609990 | pubmed:author | pubmed-author:ZarlingJ MJM | lld:pubmed |
| pubmed-article:6609990 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6609990 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:6609990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6609990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6609990 | pubmed:pagination | 422-7 | lld:pubmed |
| pubmed-article:6609990 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:meshHeading | pubmed-meshheading:6609990-... | lld:pubmed |
| pubmed-article:6609990 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6609990 | pubmed:articleTitle | Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens. | lld:pubmed |
| pubmed-article:6609990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6609990 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6609990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609990 | lld:pubmed |
