| pubmed-article:6609070 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C0020967 | lld:lifeskim |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C0028013 | lld:lifeskim |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:6609070 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6609070 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6609070 | pubmed:dateCreated | 1984-5-30 | lld:pubmed |
| pubmed-article:6609070 | pubmed:abstractText | The effects of nickel chloride on the cellular and humoral immune responses of mice were studied. A single intramuscular injection of nickel chloride (18.3 mg/kg) caused a significant involution of the thymus within 2 days following treatment. Significant reductions in the in vitro mitogen-stimulated response of lymphocytes from nickel chloride-treated mice (24 hr following a single injection of 18.3 or 36.6 mg/kg) were observed for the T-cell mitogens phytohemagglutinin (PHA) and concanavalin A (Con A), and the B- and T-cell mitogen pokeweed mitogen (PWM) but not the B-cell mitogen lipopolysaccharide (LPS). Theta-positive but not Ig-positive spleen cells were significantly reduced in nickel-treated mice compared with controls. Significant suppression of the primary antibody response to the T-cell dependent antigen sheep red blood cells was observed following a single injection of 18.3 mg/kg NiCl2. Natural killer (NK) cell activity was significantly suppressed following a single injection of 18.3 mg/kg NiCl2. The administration of NiCl2 (18.3 mg/kg) also decreased the amount of endotoxin required to kill 50% of treated mice, although this was not statistically significant. In all cases the immunosuppressive effects of NiCl2 were found to be transient with responses returning to normal within a few days. No alteration in the response of mice immunized with the T-cell independent antigen polyvinylpyrrolidone was observed following treatment with nickel. Furthermore, the phagocytic capacity of resident peritoneal macrophages from nickel-treated mice was not significantly different from saline-injected mice. The results indicate that NiCl2 predominantly affects T-cell mediated immune responses and natural killer cells. | lld:pubmed |
| pubmed-article:6609070 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6609070 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609070 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6609070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6609070 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6609070 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6609070 | pubmed:issn | 0013-9351 | lld:pubmed |
| pubmed-article:6609070 | pubmed:author | pubmed-author:SmialowiczR... | lld:pubmed |
| pubmed-article:6609070 | pubmed:author | pubmed-author:RogersR RRR | lld:pubmed |
| pubmed-article:6609070 | pubmed:author | pubmed-author:RiddleM MMM | lld:pubmed |
| pubmed-article:6609070 | pubmed:author | pubmed-author:StottG AGA | lld:pubmed |
| pubmed-article:6609070 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6609070 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:6609070 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6609070 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6609070 | pubmed:pagination | 413-27 | lld:pubmed |
| pubmed-article:6609070 | pubmed:dateRevised | 2006-10-30 | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
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| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:meshHeading | pubmed-meshheading:6609070-... | lld:pubmed |
| pubmed-article:6609070 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6609070 | pubmed:articleTitle | Immunologic effects of nickel: I. Suppression of cellular and humoral immunity. | lld:pubmed |
| pubmed-article:6609070 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6609070 | lld:pubmed |
