| pubmed-article:6603879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6603879 | lifeskim:mentions | umls-concept:C1257792 | lld:lifeskim |
| pubmed-article:6603879 | lifeskim:mentions | umls-concept:C0026484 | lld:lifeskim |
| pubmed-article:6603879 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6603879 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:6603879 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:6603879 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6603879 | pubmed:dateCreated | 1983-10-8 | lld:pubmed |
| pubmed-article:6603879 | pubmed:abstractText | Human umbilical vein endothelial cells were cultured in supernatants of peripheral blood monocytes that had been cultured for 3 days with and without lactoferrin. Colony-stimulating activity (CSA) was measured in supernatants of the endothelial cell cultures and appropriate control cultures using normal, T-lymphocyte-depleted, phagocyte-depleted, low-density bone marrow cells in colony growth (CFU-GM) assays. Monocyte-conditioned medium contained a nondialyzable, heat labile factor that enhanced 4-15--fold the production of CSA by endothelial cells. The addition of lactoferrin to monocyte cultures reduced the activity of this monokine by 69%. Lactoferrin did not inhibit CSA production by monokine-stimulated endothelial cells. Therefore, vascular endothelial cells are potent sources of CSA, the production of CSA by these cells is regulated by a stimulatory monokine, and the production and/or release of the monokine is inhibited by lactoferrin, a neutrophil-derived putative feedback inhibitor of granulopoiesis. Inasmuch as a similar monokine is known to stimulate CSA production by fibroblasts and T lymphocytes, we suggest that mononuclear phagocytes play a pivotal role in the regulation of granulopoiesis by recruiting a variety of cell types to produce CSA. | lld:pubmed |
| pubmed-article:6603879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6603879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6603879 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6603879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6603879 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6603879 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:6603879 | pubmed:author | pubmed-author:McCallEE | lld:pubmed |
| pubmed-article:6603879 | pubmed:author | pubmed-author:BurgerDD | lld:pubmed |
| pubmed-article:6603879 | pubmed:author | pubmed-author:BagbyG CGCJr | lld:pubmed |
| pubmed-article:6603879 | pubmed:author | pubmed-author:BergstromK... | lld:pubmed |
| pubmed-article:6603879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6603879 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:6603879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6603879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6603879 | pubmed:pagination | 663-8 | lld:pubmed |
| pubmed-article:6603879 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:6603879 | pubmed:meshHeading | pubmed-meshheading:6603879-... | lld:pubmed |
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| pubmed-article:6603879 | pubmed:meshHeading | pubmed-meshheading:6603879-... | lld:pubmed |
| pubmed-article:6603879 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6603879 | pubmed:articleTitle | A monokine regulates colony-stimulating activity production by vascular endothelial cells. | lld:pubmed |
| pubmed-article:6603879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6603879 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:6603879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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