| pubmed-article:6587335 | pubmed:abstractText | The ability of prostaglandin E2 (PGE2) to mobilize 45Ca from chick embryo long bones was assayed in an in vitro bone culture system. Concentrations of PGE2 tested ranged from 10(-9) to 10(-5) M. The PGE2 was effective in stimulating release of 45Ca from prelabelled bones at all concentrations tested except at 10(-9) M. In addition, stimulation of 45Ca release could be produced daily for 4 consecutive days of PGE2 culture-pulsing at what appeared to be the optimal PGE2 concentration, 10(-7) M. We conclude, as in mammals, PGE2 is a potent stimulator of calcium mobilization from avian bone. The potential involvement of prostaglandins in eggshell formation is discussed. | lld:pubmed |
