| pubmed-article:6582788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:6582788 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6582788 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6582788 | pubmed:dateCreated | 1984-3-23 | lld:pubmed |
| pubmed-article:6582788 | pubmed:abstractText | Human leukemic promyelocytes of the HL-60 line were grown as tumors in nude mice and studied. A single nonmetastatic granulocytic sarcoma developed after subcutaneous inoculation with HL-60 cells. Some exceeded 5 cm in size. Almost all mice developed tumors after initial priming with cyclophosphamide. Older sarcomas showed viable tumor islands in necrotic and fibrotic tissue. Some tumors appeared greenish. Histologic and electron-microscopic analysis demonstrated large, vaguely outlined cells in poorly vascularized sheets. The cells displayed high nucleocytoplasmic ratios, basophilic granular cytoplasms lacking Auer rods, and enzymes characteristic of cultured HL-60 promyelocytes. Some tumor cells also demonstrated monocyte/macrophage enzymes, such as butyrate esterase. Induced HL-60 tumors also corresponded morphologically to a human subcutaneous promyelocytic tumor specimen. Comparative cytologic studies of induced HL-60 tumors in nude mice and cultured HL-60 cells revealed virtual identity, suggesting the nude mouse tumor as a useful model for in vivo studies of human leukemic cells. | lld:pubmed |
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| pubmed-article:6582788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6582788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6582788 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6582788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6582788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6582788 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6582788 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:6582788 | pubmed:author | pubmed-author:ChiaoJ WJW | lld:pubmed |
| pubmed-article:6582788 | pubmed:author | pubmed-author:PotterG KGK | lld:pubmed |
| pubmed-article:6582788 | pubmed:author | pubmed-author:ShenR NRN | lld:pubmed |
| pubmed-article:6582788 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6582788 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:6582788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6582788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6582788 | pubmed:pagination | 360-6 | lld:pubmed |
| pubmed-article:6582788 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6582788 | pubmed:meshHeading | pubmed-meshheading:6582788-... | lld:pubmed |
| pubmed-article:6582788 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6582788 | pubmed:articleTitle | Nude mice as models for human leukemia studies. | lld:pubmed |
| pubmed-article:6582788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6582788 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
