| pubmed-article:6581360 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0035412 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0332282 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C1550605 | lld:lifeskim |
| pubmed-article:6581360 | lifeskim:mentions | umls-concept:C0456205 | lld:lifeskim |
| pubmed-article:6581360 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6581360 | pubmed:dateCreated | 1984-2-22 | lld:pubmed |
| pubmed-article:6581360 | pubmed:abstractText | Karyotype patterns, growth, metastasis, and immunogenicity were compared in a rhabdomyosarcoma induced by a single injection of metallic nickel with those in subsequent tumor-cloned cell lines. The primary tumor was induced in a male WAG rat by im injection of 20 mg nickel powder. The parental cell line (9-4/0) and 8 cell subpopulations (J 9-4) isolated from a primary tumor by cloning on agarose were examined. The tumor cell dose inducing tumors in 50% of the animals after sc injection (TD50) and the in vitro growth characteristics showed a marked heterogeneity between parental and cloned tumor cell lines. In vitro doubling times and saturation densities were also heterogeneous without showing a discernible relationship with TD50. Chromosome patterns of the cell lines exhibited very similar modal numbers, whereas chromosome numbers were somewhat different; neither of these exhibited any correlation with tumorigenicity. Parental cell line 9-4/0 expressed a significant degree of immunogenicity, but it did not protect against pulmonary metastasis in immunized rats. Among 6 clones studied, only clone J 9-4/2 appeared to be immunogenic and reduced metastatic spread. The relevance of the comparison between the different characteristics is discussed. | lld:pubmed |
| pubmed-article:6581360 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6581360 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6581360 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6581360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6581360 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6581360 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6581360 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:6581360 | pubmed:author | pubmed-author:PouponM FMF | lld:pubmed |
| pubmed-article:6581360 | pubmed:author | pubmed-author:Chouroulinkov... | lld:pubmed |
| pubmed-article:6581360 | pubmed:author | pubmed-author:Pot-DeprunJJ | lld:pubmed |
| pubmed-article:6581360 | pubmed:author | pubmed-author:SweeneyF LFL | lld:pubmed |
| pubmed-article:6581360 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6581360 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:6581360 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6581360 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6581360 | pubmed:pagination | 1241-5 | lld:pubmed |
| pubmed-article:6581360 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:meshHeading | pubmed-meshheading:6581360-... | lld:pubmed |
| pubmed-article:6581360 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6581360 | pubmed:articleTitle | Growth, metastasis, immunogenicity, and chromosomal content of a nickel-induced rhabdomyosarcoma and subsequent cloned cell lines in rats. | lld:pubmed |
| pubmed-article:6581360 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6581360 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6581360 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6581360 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6581360 | lld:pubmed |
