pubmed-article:6542494 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C0426857 | lld:lifeskim |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C1136735 | lld:lifeskim |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C0017857 | lld:lifeskim |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C0017363 | lld:lifeskim |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C0033799 | lld:lifeskim |
pubmed-article:6542494 | lifeskim:mentions | umls-concept:C1414968 | lld:lifeskim |
pubmed-article:6542494 | pubmed:issue | 11 | lld:pubmed |
pubmed-article:6542494 | pubmed:dateCreated | 1985-2-19 | lld:pubmed |
pubmed-article:6542494 | pubmed:abstractText | A human X chromosome-derived gene sequence which recognises an abundant, 1.2-kb mRNA in several cell types was previously isolated during a study to identify expressed sequences from an X chromosome recombinant library. Further characterisation of this clone, acronym OA1, has shown that it maps to the short arm of the X, at Xp21 to Xp22. A 777-bp fragment of the clone which hybridizes to the 1.2-kb mRNA has been sequenced, and the inferred amino acid sequence shows 80% homology with the published protein sequence for human muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The fragment shows even higher homology (87%) with pig muscle GAPDH. The OA1 clone selects an mRNA which translates in vitro into a polypeptide of 36 K, the subunit size of GAPDH. However, the X-sequence is most probably a pseudogene whose structure is consistent with it having arisen by reverse transcription of a GAPDH or GAPDH-related mRNA followed by insertion into the X chromosome. The GAPDH-related portion of OA1 hybridizes to several DNA fragments in human and mouse DNA, and six fibroblast cDNA clones which cross-hybridize to OA1 identify the same genomic fragments as OA1. This series of clones identifies a new, conserved GAPDH-related multigene family. | lld:pubmed |
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pubmed-article:6542494 | pubmed:language | eng | lld:pubmed |
pubmed-article:6542494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6542494 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6542494 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6542494 | pubmed:month | Nov | lld:pubmed |
pubmed-article:6542494 | pubmed:issn | 0261-4189 | lld:pubmed |
pubmed-article:6542494 | pubmed:author | pubmed-author:BenhamF JFJ | lld:pubmed |
pubmed-article:6542494 | pubmed:author | pubmed-author:DaviesK EKE | lld:pubmed |
pubmed-article:6542494 | pubmed:author | pubmed-author:HodgkinsonSS | lld:pubmed |
pubmed-article:6542494 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6542494 | pubmed:volume | 3 | lld:pubmed |
pubmed-article:6542494 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6542494 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6542494 | pubmed:pagination | 2635-40 | lld:pubmed |
pubmed-article:6542494 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:6542494 | pubmed:year | 1984 | lld:pubmed |
pubmed-article:6542494 | pubmed:articleTitle | A glyceraldehyde-3-phosphate dehydrogenase pseudogene on the short arm of the human X chromosomes defines a multigene family. | lld:pubmed |
pubmed-article:6542494 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6542494 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:6542494 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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