| pubmed-article:6529533 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6529533 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:6529533 | lifeskim:mentions | umls-concept:C0054640 | lld:lifeskim |
| pubmed-article:6529533 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6529533 | pubmed:dateCreated | 1985-5-10 | lld:pubmed |
| pubmed-article:6529533 | pubmed:abstractText | Concentrations of carbamazepine (CBZ) and its 10,11-epoxide metabolite (CBZ-E) were measured in simultaneously collected plasma and mixed saliva samples from 15 children (aged 1-13 years). Saliva concentrations of CBZ and CBZ-E were measured in hourly samples taken from six of these children during dose intervals whilst on different dose or dose-frequency regimens. Saliva and plasma CBZ (r = 0.91; P less than 0.001) and CBZ-E (r = 0.91; P less than 0.001) concentrations were significantly correlated. The mean +/- s.d. steady state CBZ-E/CBZ concentration ratio in the six children was 0.40 +/- 0.21 and was similar at all times within the 12 h dose interval. The mean +/- s.d. percentage fluctuation of the combined CBZ + CBZ-E (103.0 +/-28.9) was significantly less than that of CBZ-E (145.5 +/- 52.8) but not CBZ (109.6 +/- 31.1). If CBZ and CBZ-E have equipotent anticonvulsant activity in man, the contribution of CBZ-E approximates to 30% of total anticonvulsant effect in children taking CBZ alone. | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6529533 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6529533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6529533 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6529533 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6529533 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:6529533 | pubmed:author | pubmed-author:EdwardsCC | lld:pubmed |
| pubmed-article:6529533 | pubmed:author | pubmed-author:GrayG FGF | lld:pubmed |
| pubmed-article:6529533 | pubmed:author | pubmed-author:RylanceG WGW | lld:pubmed |
| pubmed-article:6529533 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6529533 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:6529533 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6529533 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6529533 | pubmed:pagination | 935-9 | lld:pubmed |
| pubmed-article:6529533 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:meshHeading | pubmed-meshheading:6529533-... | lld:pubmed |
| pubmed-article:6529533 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6529533 | pubmed:articleTitle | Carbamazepine 10,11-epoxide in children. | lld:pubmed |
| pubmed-article:6529533 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6529533 | pubmed:publicationType | Comparative Study | lld:pubmed |
