| pubmed-article:6527212 | pubmed:abstractText | Induction effect of phenobarbital (80 mg/kg, daily for 4 d), 3-methylcholanthrene (40 mg/kg, daily for 4 d), and isosafrole (150 mg/kg, daily for 4 d), on 2- and 4-hydroxylations of estradiol 17-sulfate by rat liver microsomes with an NADPH-generating system was investigated. On catechol formation from estradiol 17-sulfate, only phenobarbital caused some increase of the 2-hydroxylase activity in both sexes. While 4-hydroxylase activity was caused effectively by phenobarbital and isosafrole in both sexes, especially, the induction by the former in male rats was over six-fold increase to the control. | lld:pubmed |
