| pubmed-article:6491603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6491603 | lifeskim:mentions | umls-concept:C2754943 | lld:lifeskim |
| pubmed-article:6491603 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:6491603 | lifeskim:mentions | umls-concept:C2702333 | lld:lifeskim |
| pubmed-article:6491603 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:6491603 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:6491603 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6491603 | pubmed:dateCreated | 1984-12-7 | lld:pubmed |
| pubmed-article:6491603 | pubmed:abstractText | A new natural anti-alpha-galactosyl IgG antibody (anti-Gal) was found to be present in high titer in the serum of every normal individual studied. The antibody was isolated by affinity chromatography on a melibiose-Sepharose column. The reactivity of the antibody was assessed by its interaction with alpha-galactosyl residues on rabbit erythrocytes (RabRBC). The specificity was determined by inhibition experiments with various carbohydrates. The anti-Gal interacts with alpha-galactosyl residues, possibly on glycolipids of human RBC (HuRBC), after removal of membrane proteins by treatment with pronase. In addition, the anti-Gal bind specifically to normal and pathologically senescent HuRBC, suggesting a physiological role for this natural antibody in the aging of RBC. The ubiquitous presence of anti-Gal in high titers throughout life implies a constant antigenic stimulation. In addition to the theoretical interest in the antibody, the study of the anti-Gal reactivity seems to bear immunodiagnostic significance. Decrease in the antibody titer was found to reflect humoral immunodeficiency disorders. | lld:pubmed |
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| pubmed-article:6491603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6491603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6491603 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6491603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6491603 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6491603 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6491603 | pubmed:author | pubmed-author:GaliliUU | lld:pubmed |
| pubmed-article:6491603 | pubmed:author | pubmed-author:RachmilewitzE... | lld:pubmed |
| pubmed-article:6491603 | pubmed:author | pubmed-author:PeledNN | lld:pubmed |
| pubmed-article:6491603 | pubmed:author | pubmed-author:FlechnerII | lld:pubmed |
| pubmed-article:6491603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6491603 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6491603 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:6491603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6491603 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6491603 | pubmed:pagination | 1519-31 | lld:pubmed |
| pubmed-article:6491603 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:6491603 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6491603 | pubmed:articleTitle | A unique natural human IgG antibody with anti-alpha-galactosyl specificity. | lld:pubmed |
| pubmed-article:6491603 | pubmed:publicationType | Journal Article | lld:pubmed |
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