| pubmed-article:6488689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0020365 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0011082 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0011685 | lld:lifeskim |
| pubmed-article:6488689 | lifeskim:mentions | umls-concept:C0332529 | lld:lifeskim |
| pubmed-article:6488689 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6488689 | pubmed:dateCreated | 1984-12-7 | lld:pubmed |
| pubmed-article:6488689 | pubmed:abstractText | The 2-hydroxylation of desmethylimipramine (DMI) and the 4-hydroxylation of debrisoquine (D) were studied in healthy subjects and in human liver microsomes. A single oral dose of DMI (25 mg) was given to 18 healthy subjects previously phenotyped with D (13 rapid and five slow hydroxylators). Urine was collected for 24 hr and DMI and total 2-hydroxydesmethylimipramine (2-OH-DMI) levels were determined by HPLC. The urinary ratio DMI/2-OH-DMI correlated strongly (r = 0.92) with the urinary ratio of D to 4-hydroxydebrisoquine (D/4-OH-D). The two hydroxylations were also studied in human liver microsomes from 10 different subjects. Formation rates of the hydroxylated metabolites correlated strongly (r = 0.869). Moreover, D competitively inhibited the 2-hydroxylation of DMI. These findings suggest that both are hydroxylated by the same cytochrome P-450 isozyme. | lld:pubmed |
| pubmed-article:6488689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6488689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6488689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6488689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6488689 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6488689 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:von BahrCC | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:SjöqvistFF | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:EricssonOO | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:SteinerEE | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:MellströmBB | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:SpinaEE | lld:pubmed |
| pubmed-article:6488689 | pubmed:author | pubmed-author:BirgerssonCC | lld:pubmed |
| pubmed-article:6488689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6488689 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:6488689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6488689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6488689 | pubmed:pagination | 677-82 | lld:pubmed |
| pubmed-article:6488689 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
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| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
| pubmed-article:6488689 | pubmed:meshHeading | pubmed-meshheading:6488689-... | lld:pubmed |
| pubmed-article:6488689 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6488689 | pubmed:articleTitle | Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes. | lld:pubmed |
| pubmed-article:6488689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6488689 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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