| pubmed-article:6460832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6460832 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6460832 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:6460832 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:6460832 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6460832 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6460832 | pubmed:dateCreated | 1982-5-21 | lld:pubmed |
| pubmed-article:6460832 | pubmed:abstractText | Previous studies demonstrated that lymphoid tissues of mice and rats contain small numbers (less than 1 percent of nucleated cells) of dendritic cells (DC) with special cytologic, surface, and functional properties. We show here that similar DC represent 0.1-0.5 percent of human peripheral blood mononuclear cells. DC can be enriched to 20-60 percent purity by a multistep procedure analogous to that used in mice. Adherent peripheral blood mononuclear cells are cultured overnight, and the released cells are depleted of monocytes and B cells by readherence to plastic, rosetting with erythrocytes coated with anti-human IgG, and centrifugation in dense albumin columns. Enriched DC have similar cytologic features to rodent DC by light and electron microscopy. DC express HLA, and HLA-DR and the leukocyte-common antigens. They lack phagocytic capacity, receptors for antibody-coated and neuraminidase-treated erythrocytes, surface and intracellular Ig, esterase, peroxidase, and azurophilic granules. DC do not react with several monoclonal antibodies directed to phagocytes (OKM 1, "mac-1," 63D3, and 61D3) and T cells (OKT 3, 6, 8). Unlike the mouse, human DC express complement receptors. When maintained in culture for 4 d, human DC did not give rise to either B cells or monocytes. Therefore, DC identified by cytologic criteria are distinct from other leukocytes. Enriched populations of DC have been compared to fractions enriched in monocytes, B cells, and T cells in three functional assays: stimulation of the primary allogeneic mixed leukocyte reaction, stimulation of the primary syngeneic MLR, and accessory function for the proliferation of periodate- modified T cells. In each case, the DC fraction was 10-fold or more active than other cell fractions. We conclude that DC circulate in man, and represent the principal cell type required for the initiation of several immune responses. | lld:pubmed |
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| pubmed-article:6460832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6460832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6460832 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6460832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6460832 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6460832 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6460832 | pubmed:author | pubmed-author:KaplanGG | lld:pubmed |
| pubmed-article:6460832 | pubmed:author | pubmed-author:SteinmanR MRM | lld:pubmed |
| pubmed-article:6460832 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:6460832 | pubmed:author | pubmed-author:HairL SLS | lld:pubmed |
| pubmed-article:6460832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6460832 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6460832 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:6460832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6460832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6460832 | pubmed:pagination | 1172-87 | lld:pubmed |
| pubmed-article:6460832 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:6460832 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6460832 | pubmed:articleTitle | Human dendritic cells. Enrichment and characterization from peripheral blood. | lld:pubmed |
| pubmed-article:6460832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6460832 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6460832 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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