| pubmed-article:6456304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:6456304 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:6456304 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6456304 | pubmed:dateCreated | 1981-11-22 | lld:pubmed |
| pubmed-article:6456304 | pubmed:abstractText | A variety of approaches, including the use of a monoclonal antibody, have indicated that the lymphokine Interleukin 2 is a necessary and sufficient mediator for initiating cytotoxic T cell differentiation in vitro. Mitogen (Con A, PHA) stimulation of spleen cells and K/D or I region stimulation in primary MLC all led to IL-2 production, as measured by the growth of an IL-2 dependent T cell clone, and to the production of a "helper" factor necessary for cytotoxic T lymphocyte (CTL) differentiation against metabolically inactivated stimulator spleen cells. Several lines of evidence suggested that the IL-2 activity and CTL "helper" activity were due to a single molecular entity. These included the observations that: i) There was a linear relationship (R = 0.99) between IL-2 activity and relative CTL "helper" activity regardless of the preparation used (purified IL-2; MLC, or mitogen-induced supernatants). ii) Absorption of MLC supernatants with T cell "blasts" or with IL-2 dependent T cell lines concomitantly removed both IL-2 and CTL "helper" activities. iii) IL-2 activity purified by isoelectric focusing, or by polyacrylamide gel electrophoresis, displayed CTL "helper" activity. iv) Both CTL "helper" and IL-2 activities were neutralized by a monoclonal antibody directed against IL-2. | lld:pubmed |
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| pubmed-article:6456304 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6456304 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6456304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6456304 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6456304 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6456304 | pubmed:author | pubmed-author:OkadaMM | lld:pubmed |
| pubmed-article:6456304 | pubmed:author | pubmed-author:HenneyC SCS | lld:pubmed |
| pubmed-article:6456304 | pubmed:author | pubmed-author:GillisSS | lld:pubmed |
| pubmed-article:6456304 | pubmed:author | pubmed-author:KerrD ADA | lld:pubmed |
| pubmed-article:6456304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6456304 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:6456304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6456304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6456304 | pubmed:pagination | 1323-8 | lld:pubmed |
| pubmed-article:6456304 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6456304 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6456304 | pubmed:articleTitle | The role of interleukin-2 (IL-2) in the differentiatin of cytotoxic T cells: the effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines. | lld:pubmed |
| pubmed-article:6456304 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6456304 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6456304 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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