| pubmed-article:6450262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6450262 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6450262 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:6450262 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:6450262 | lifeskim:mentions | umls-concept:C2362651 | lld:lifeskim |
| pubmed-article:6450262 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:6450262 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6450262 | pubmed:dateCreated | 1981-3-27 | lld:pubmed |
| pubmed-article:6450262 | pubmed:abstractText | A series of T cell-specific monoclonal antibodies was used to determine the location of T lymphocyte subpopulations in frozen sections of human lymph nodes by means of an immunoperoxidase technique. The majority of cells in the paracortical regions were reactive with anti-T1 and anti-T3 antibodies, which define all mature peripheral T cells. In contrast, the majority of cells within primary follicles were unreactive with anti-T1 and anti-T3 antibodies, but were reactive with anti-Ia and anti-IgM antibodies. In addition, a substantial number of T1+, T3+ cells were found in the germinal centers of secondary follicles on the capsular side. The vast majority of T1+, T3+ cells in the paracortex and the follicles were reactive with anti-T4 antibody, which defines inducer/helper T cells. Only a minority of cells in these areas were reactive with anti-T5 and anti-T8 antibodies, which define cytotoxic/suppressor cells. No lymphocytes were stained with anti-T6 antibody, which reacts with a majority of thymocytes but not with peripheral T cells. Scattered cells in the paracortex showed staining for Ia antigen in an irregular dendritic pattern. The findings demonstrate that the major T cell population found within human lymph node bears the mature T1+, T3+, T4+ phenotype characteristic of inducer T cells. Moreover, the location of this population indicates that they play a role in the induction of B cell differentiation in vivo. | lld:pubmed |
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| pubmed-article:6450262 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6450262 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6450262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6450262 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6450262 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6450262 | pubmed:author | pubmed-author:McCluskeyR... | lld:pubmed |
| pubmed-article:6450262 | pubmed:author | pubmed-author:SchlossmanS... | lld:pubmed |
| pubmed-article:6450262 | pubmed:author | pubmed-author:ReinherzE LEL | lld:pubmed |
| pubmed-article:6450262 | pubmed:author | pubmed-author:PoppemaSS | lld:pubmed |
| pubmed-article:6450262 | pubmed:author | pubmed-author:BhanA KAK | lld:pubmed |
| pubmed-article:6450262 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6450262 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6450262 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:6450262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6450262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6450262 | pubmed:pagination | 30-41 | lld:pubmed |
| pubmed-article:6450262 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6450262 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6450262 | pubmed:articleTitle | Distribution of T cell subsets in human lymph nodes. | lld:pubmed |
| pubmed-article:6450262 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6450262 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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