| pubmed-article:6448897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C2349967 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0021013 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:6448897 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6448897 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6448897 | pubmed:dateCreated | 1981-1-29 | lld:pubmed |
| pubmed-article:6448897 | pubmed:abstractText | The cellular mechanism in neonatally suppressed BALB/c mice, which maintains the chronic suppressed state of the TEPC-15 idiotype in the antibody response to phosphorylcholine (PC), was investigated. Cells taken from these suppressed mice cannot transfer suppression to adult BALB/c or affect the in vitro response to PC of adult BALB/c spleen cells. However, spleen cells or T cells from neonatally suppressed mice given to neonatal animals induce chronic suppression of the TEPC-15 idiotype in the anti-PC response. Co-transfer of T cells from neonatally suppressed cells with normal T cells prevented the induction of suppression in neonates. Transfer of T cells from normal or keyhole limpet hemocyanin-primed BALB/c increased the expression of TEPC-15 idiotype in chronically suppressed mice, whereas T cells from neonatally suppressed were ineffective. These findings show that T cells in neonatally suppressed mice can affect the development of immature but not mature cells. The restoration of TEPC-15 expression in neonatally suppressed animals by normal T cells and the failure to induce suppression in neonates by co-transfers of T cells from normal and chronically suppressed mice demonstrate the profound role of an altered T cell compartment in sustaining chronic idiotype suppression. | lld:pubmed |
| pubmed-article:6448897 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6448897 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6448897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6448897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6448897 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6448897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6448897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6448897 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6448897 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6448897 | pubmed:author | pubmed-author:KöhlerHH | lld:pubmed |
| pubmed-article:6448897 | pubmed:author | pubmed-author:FungJJ | lld:pubmed |
| pubmed-article:6448897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6448897 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:6448897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6448897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6448897 | pubmed:pagination | 2489-95 | lld:pubmed |
| pubmed-article:6448897 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:meshHeading | pubmed-meshheading:6448897-... | lld:pubmed |
| pubmed-article:6448897 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6448897 | pubmed:articleTitle | Mechanism of neonatal idiotype suppression. II. Alterations in the T cell compartment suppress the maturation of B cell precursors. | lld:pubmed |
| pubmed-article:6448897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6448897 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6448897 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6448897 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6448897 | lld:pubmed |
