| pubmed-article:6446903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0002565 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0041256 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0018966 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:6446903 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:6446903 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6446903 | pubmed:dateCreated | 1980-9-23 | lld:pubmed |
| pubmed-article:6446903 | pubmed:abstractText | Rat liver tryptophan pyrrolase haem is maximally depleted at 30 min after administration of a 400 mg/kg dose of 2-allyl-2-isopropylacetamide. This depletion lasts for 24 h, by which time 5-aminoleevulinate synthase activity becomes maximally enhanced. 2. though the above maximum depletion of pyrrolase haem (at 0.5h) is also produced by a 100 mg/kg dose of the porphyrogen, this does not enhance synthase activity at 24 h. It and smaller doses, however, cause a smaller but earlier enhancement of synthase activity (maximum at 2 h) and produce a similarly short-lived deplation of pyrrolase haem. 3. The depletion of pyrrolase haem and the enhancement of synthase activity by the porphyrogen are inhibited by compound SKF 525-A and phenazine methosulphate, and are potentiated by nicotinamide but not by phenobarbitone. Phenazine methosulphate and nicotinamide also exert opposite effects on hexobarbital sleeping-time. 4. 2-Allyl-2-isopropylacetamde also the depletes pyrrolase haem in vitro. It does so in liver homogenates of control rats in the presence, and in those of phenobarbitone-treated rats in the absence of added NADPH. 5. A discussion of the present results in relation to previous work with other haemoproteins suggests that, whereas cytochrome P-450 (haem) is primarily involved in the production of the active (porphyrogenic) metabolite(s) of 2-allyl-2-isopropylacetamide, the haem pool used by tryptophan pyrrolase may play an important role in the effects of this compound on haem biosynthesis. | lld:pubmed |
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| pubmed-article:6446903 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6446903 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6446903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6446903 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6446903 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6446903 | pubmed:author | pubmed-author:BadawyA AAA | lld:pubmed |
| pubmed-article:6446903 | pubmed:author | pubmed-author:MorganC JCJ | lld:pubmed |
| pubmed-article:6446903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6446903 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6446903 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:6446903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6446903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6446903 | pubmed:pagination | 763-72 | lld:pubmed |
| pubmed-article:6446903 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6446903 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6446903 | pubmed:articleTitle | Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide. | lld:pubmed |
| pubmed-article:6446903 | pubmed:publicationType | Journal Article | lld:pubmed |
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