| pubmed-article:6438156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0023317 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0010422 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6438156 | lifeskim:mentions | umls-concept:C0598528 | lld:lifeskim |
| pubmed-article:6438156 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6438156 | pubmed:dateCreated | 1984-12-24 | lld:pubmed |
| pubmed-article:6438156 | pubmed:abstractText | We have examined the nonenzymatic glycation of human lens crystallin, an extremely long-lived protein, from 16 normal human ocular lenses 0.2-99 yr of age, and from 11 diabetic lenses 52-82-yr-old. The glucitol-lysine (Glc-Lys) content of soluble and insoluble crystallin was determined after reduction with H-borohydride followed by acid hydrolysis, boronic acid affinity chromatography, and high pressure cation exchange chromatography. Normal lens crystallin, soluble and insoluble, had 0.028 +/- 0.011 nanomoles Glc-Lys per nanomole crystallin monomer. Soluble and insoluble crystallins had equivalent levels of glycation. The content of Glc-Lys in normal lens crystallin increased with age in a linear fashion. Thus, the nonenzymatic glycation of nondiabetic lens crystallin may be regarded as a biological clock. The diabetic lens crystallin samples (n = 11) had a higher content of Glc-Lys (0.070 +/- 0.034 nmol/nmol monomer). Over an age range comparable to that of the control samples, the diabetic crystallin samples contained about twice as much Glc-Lys. The Glc-Lys content of the diabetic lens crystallin samples did not increase with lens age. | lld:pubmed |
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| pubmed-article:6438156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6438156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6438156 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6438156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6438156 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6438156 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:6438156 | pubmed:author | pubmed-author:ChylackL... | lld:pubmed |
| pubmed-article:6438156 | pubmed:author | pubmed-author:BunnH FHF | lld:pubmed |
| pubmed-article:6438156 | pubmed:author | pubmed-author:RabyCC | lld:pubmed |
| pubmed-article:6438156 | pubmed:author | pubmed-author:GarlickR LRL | lld:pubmed |
| pubmed-article:6438156 | pubmed:author | pubmed-author:MazerJ SJS | lld:pubmed |
| pubmed-article:6438156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6438156 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:6438156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6438156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6438156 | pubmed:pagination | 1742-9 | lld:pubmed |
| pubmed-article:6438156 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6438156 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6438156 | pubmed:articleTitle | Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus. | lld:pubmed |
| pubmed-article:6438156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6438156 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6438156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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