| pubmed-article:6431411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0221928 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C1334545 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0063356 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:6431411 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:6431411 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:6431411 | pubmed:dateCreated | 1984-9-19 | lld:pubmed |
| pubmed-article:6431411 | pubmed:abstractText | Immune interferon (IFN-gamma) increases the surface expression of HLA-A,B antigens and induces the surface expression of HLA-DR antigens on vascular endothelial cells and dermal fibroblasts. Here we report that IFN-gamma induces parallel expression of two other class II major histocompatibility complex (MHC) antigens, SB and DC. Maximal surface expression of all three antigens is reached in 4-6 days, and HLA-DR and -SB are induced to a higher level of expression than HLA-DC. For all three class II antigens, induction is marked by the de novo appearance of detectable transcripts of class II heavy and light chains and of the non-MHC-encoded invariant chain, suggestive of the transcription of multiple previously silent genes. Class I message levels and antigen expression are also increased by IFN-gamma at similar rates but from initial levels that are 50% of maximal. After removal of IFN-gamma, class II antigen expression persists for at least 4 days, while mRNA levels decrease rapidly. The parallel induction and persistence of the several class II MHC antigens may be important in conferring immune accessory function on vascular and stromal cells. | lld:pubmed |
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| pubmed-article:6431411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6431411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6431411 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6431411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6431411 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6431411 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:StromingerJ... | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:PoberJ SJS | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:WakeC TCT | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:FiersWW | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:AultK AKA | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:BossJ MJM | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:GimbroneM... | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:CollinsTT | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:KormanA JAJ | lld:pubmed |
| pubmed-article:6431411 | pubmed:author | pubmed-author:KappesD JDJ | lld:pubmed |
| pubmed-article:6431411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6431411 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6431411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6431411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6431411 | pubmed:pagination | 4917-21 | lld:pubmed |
| pubmed-article:6431411 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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